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Effect of Noise Color on Oxidative Stress Responses in Wistar Rats
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Vida Rezaei1    , Mohammadreza Monazzam Esmaeelpour |
| 1- , rezaeividaoh@gmail.com |
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Abstract: (37 Views) |
Background and Aim: Oxidative stress is one of the major mechanisms involved in noise-induced hearing loss; however, the role of the frequency distribution of noise in determining the magnitude of this response remains unclear. This study aimed to compare changes in oxidative stress markers following exposure to different noise colors in Wistar rats.
Materials and Methods: In this experimental study, 36 male Wistar rats were divided into four groups: control, white noise, pink noise, and violet noise. The exposure groups were subjected to noise at 110 dB SPL continuously for 4 h/day over 14 consecutive days. Serum malondialdehyde (MDA), superoxide dismutase (SOD) activity, and total antioxidant capacity (TAC) were measured on days 7, 14, and 21. Data were analyzed using Kruskal–Wallis test followed by Dunns’s multiple comparisons test.
Results: Despite differences in frequency content, all three noise colors produced a similar pattern of changes in oxidative stress markers. MDA levels were higher, whereas SOD activity and TAC were lower, in all noise-exposed groups than in the control group at all assessment points (P<0.05). No sufficient statistical evidence was found for differences in these markers between days 7, 14, and 21 within the exposure groups. Differences from the control group were still present on day 21.
Conclusion: Exposure to white, pink, and violet noise was associated with increased lipid peroxidation and reduced serum antioxidant defense. The observation of altered serum oxidative markers one week after cessation of noise exposure suggests that noise-related oxidative changes may continue during the short-term post-exposure period. |
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| Keywords: Noise, Noise-induced hearing loss, Oxidative stress, Noise color. |
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Type of Study: Original Research |
Subject:
Occupational Health Engineering
Received: 2026/08/8 | Accepted: 2026/09/26
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