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Molecular evaluation of the relationship between the AdeABC efflux pump with antibiotic resistance patterns in clinical isolates of Acinetobacter baumannii
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Razieh Nazari1    , Mahnaz Zarei2 |
1- Department of Microbiology, Qo. C, Islamic Azad University, Qom, Iran , Razieh.nazari@iau.ac.ir
2- Department of Microbiology, Qo. C, Islamic Azad University, Qom, Iran |
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Abstract: (355 Views) |
Background and Aim: Acinetobacter baumannii is capable of causing various nosocomial infections due to the presence of multiple factors that contribute to antibiotic resistance, such as efflux pumps. This study aimed to investigate the frequency of AdeABC efflux pump genes and their regulatory system in A. baumannii isolates and evaluate their relationship with antimicrobial resistance.
Materials and Methods: The antibiotic resistance pattern in 100 isolates of A. baumannii was studied by the disk diffusion method. Subsequently, the presence of adeA, adeB, and adeC genes and regulatory genes (adeR and adeS) in the isolates was investigated by the PCR method. The results were analyzed using the Chi-square test through SPSS software (version 16).
Results: This study showed that among the isolates of A. baumannii, 86 isolates had the adeA gene, 80 isolates had the adeB gene, 66 isolates had the adeC gene, 81 isolates had the adeR gene, and 78 isolates had the adeS gene. The presence of the adeA and adeR genes among the isolates was higher than that of the other genes.
Conclusion: The results showed that A. baumannii isolates were more than 95% resistant to most antibiotics, and the adeA, adeB, adeR, and adeS genes were present in more than 75% of them, which is consistent with the high drug resistance phenotype observed in the isolates. |
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| Keywords: Acinetobacter baumannii, Antibiotic resistance, Efflux pump |
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Full-Text [PDF 849 kb]
(71 Downloads)
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Type of Study: Original Research |
Subject:
Microbiology
Received: 2026/05/29 | Accepted: 2026/08/2 | Published: 2026/09/8
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