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Study of the frequency of bacterial genes clbA, clbB, clbS, and clbQ genes in patients with ulcerative colitis
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Leila Jafari1    , Amjad Ahmadi2 , Arezou Taherpour3 , Farshad Sheikhesmaili , Nadeih Baniasadi4 , Mohammad Rahimzadeh5 , Masdoud Moradi6 |
1- . Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran
2- Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran & Zoonoses Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran , amjad.ahmadi@muk.ac.ir
3- Zoonoses Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
4- Noncommunicable Diseases Research Center, Bam University of Medical Sciences, Bam, Iran
5- Department of Microbiology, Faculty of Medicine, Kurdistan University of Medical Sciences, Kurdistan, Iran
6- Student Research Committee, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran |
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Abstract: (415 Views) |
Background and Aim: Inflammatory bowel disease, especially ulcerative colitis (UC), is associated with chronic inflammation and disruption of the intestinal microbiota. Some intestinal bacteria, such as Escherichia coli, Klebsiella pneumoniae, and Enterobacter cloacae, have a pks gene island and are capable of producing the genotoxic toxin colibactin, which may play a role in the pathogenesis of UC. This study aimed to investigate the presence of clbA, clbB, clbS, and clbQ genes in patients with ulcerative colitis.
Materials and Methods: This case-control study was conducted on 47 people with ulcerative colitis as the patient group and 47 healthy people as the control group. DNA was extracted from the stool samples of the studied individuals, and the genes under study were examined by PCR.
Results: According to the results, the mean age values of the patients and control subjects were 43.64±16.05 and 39.09±11.43, respectively. Moreover, in the patient and control groups, the study population comprised 16 females (34%) and 31 males (66%). Examination of the frequency of these genes showed that they were absent in both groups.
Conclusion: In the present study, no evidence of the presence of colibactin genes was observed in stool samples from UC patients |
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| Keywords: clbA, clbB, clbS, clbQ, Colibactin, Ulcerative colitis |
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Full-Text [PDF 825 kb]
(74 Downloads)
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Type of Study: Original Research |
Subject:
Microbiology
Received: 2026/04/13 | Accepted: 2026/07/27 | Published: 2026/09/8
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Research code: IR.MUK.REC.1404.327
Jafari L, Ahmadi A, Taherpour A, Sheikhesmaili F, Baniasadi N, Rahimzadeh M et al . Study of the frequency of bacterial genes clbA, clbB, clbS, and clbQ genes in patients with ulcerative colitis. SJKU 2026; 31 (3) URL: http://sjku.muk.ac.ir/article-1-9117-en.html
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