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A Case Report of Ganglioneuroblastoma with Non-Specific Presentations: Diagnostic and Management Challenges
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Mahmoud Khodabandeh1    , Farzad Kompani2 , Fariba Fashandaky3 , Mohammadsadegh Talebi Kahdouei4 , Katayoun Borhani3 , Hamid Eshaghi5 |
1- Associate Professor, Department of Pediatric Infectious Diseases, Pediatric's Center of Excellence, Children's Medical Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. , khodabandeh@farabi.tums.ac.ir
2- Professor, Department of Pediatric Hematology and Oncology, Pediatric's Center of Excellence, Children's Medical Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
3- Department of Pediatrics, Pediatric's Center of Excellence, Children's Medical Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
4- Fetal and Pediatric Cardiovascular Research Center, Tehran University of Medical Sciences, Tehran, Iran.
5- Associate Professor, Department of Pediatric Infectious Diseases, Pediatric's Center of Excellence, Children's Medical Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. |
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Abstract: (1022 Views) |
Background: Ganglioneuroblastoma is a rare tumor with a diverse clinical presentation, often leading to a delay in diagnosis due to nonspecific symptoms. GNB originates from neural crest cells and usually presents in early childhood. Given the diverse presentation of the patient, it can pose a diagnostic challenge. We report a case of GNB that was initially misdiagnosed as septic arthritis.
Case presentation: The case was a 25-month-old boy who presented with fever, limping, and pelvic pain and was initially diagnosed as septic arthritis. Due to the lack of response to antibiotic therapy, further investigation led to the diagnosis of metastatic GNB.
Conclusion: This case highlights the importance of considering malignancies in the differential diagnosis of musculoskeletal symptoms in children who fail to respond to initial treatment. It also highlights the critical role of advanced imaging and biopsy in reaching a definitive diagnosis.
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| Keywords: Neuroblastoma, Septic arthritis, Malignant, Infectious. |
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Full-Text [PDF 452 kb]
(28 Downloads)
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Type of Study: case report |
Subject:
Medicine - Pediatric
Received: 2025/04/27 | Accepted: 2025/11/11 | Published: 2026/04/11
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