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Investigating the Association Between Drug Interactions, Length of Hospital Stay and Number of Medications in Shohada-ye Ashayer Hospital, Khorramabad
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Leila Zarei1    , Ali Kharazmkia2 , Sobhan Bayat3 , Hadi Hayati4 |
1- Professor, Palliative Care Research Center, Urmia Branch, Islamic Azad University, Urmia, Iran.
2- Associate Professor, Department of Clinical Pharmacy, School of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran., & . Associate Professor, Clinical Research Development Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khorramabad, Iran. , kharazmkia@lums.ac.ir
3- Pharmacy Student, Student research committee, School of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran.
4- Assistant Professor, Department of Pharmacoeconomics and Management, School of Pharmacy, Lorestan University of Medical Sciences, Khorramabad, Iran. & Assistant Professor, Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorramabad, Iran. |
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Abstract: (768 Views) |
Background and Aim: Drug-Drug Interactions (DDIs) can lead to decreased therapeutic efficacy, the occurrence of serious complications, and even mortality in patients. In the intensive care unit (ICU), the likelihood of these interactions increases due to the administration of a greater number of medications. Therefore, the present study aims to investigate the frequency, severity, and risk factors associated with DDIs in hospitalized patients in the ICU and its results may contribute to improving therapeutic management and reducing complications arising from DDIs.
Materials and Methods: This cross-sectional study was conducted on 79 hospitalized patients in the ICUs of Shohadaye Ashayer Hospital in Khorramabad city from March 21, 2021, to June 21, 2021. To identify drug interactions, three online drug databases—Medscape, Epocrates and Drugs.com—were utilized. Data analysis was performed using SPSS version 21.
Results: The median length of hospital stay was 11 days with interquartile range (IQR) of 15 days (mean ± standard deviation: 14.29 ± 11.67 days). In the intensive care unit (ICU), the median length of hospital stay was approximately 7 days and IQR was 11 days (mean ± standard deviation: 11.32 ± 10.87 days). Also, the mean number of medications used per patient was 18.08 ± 8.09. In this study, there was a significant correlation between the number of DDIs and various factors such as the duration of hospitalization and the ICU and the number of medications consumed (P<0.001). Also, no significant correlation was observed between DDIs and patients' age.
Conclusion: By educating healthcare personnel about potential DDIs and their adverse effects, replacing high-interaction Drugs with alternative options, and utilizing interaction detection software, it is possible to effectively prevent DDIs and harm to patients while reducing treatment costs.
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| Keywords: drug interaction, intensive care unit, medication errors, Medscape, Epocrates, Drugs.com |
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Full-Text [PDF 536 kb]
(47 Downloads)
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Type of Study: Original Research |
Subject:
Pharmacology
Received: 2024/12/28 | Accepted: 2025/08/20 | Published: 2026/07/12
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Research code: IR.LUMS.REC.1399.368 Ethics code: IR.LUMS.REC.1399.368
Zarei L, Kharazmkia A, Bayat S, Hayati H. Investigating the Association Between Drug Interactions, Length of Hospital Stay and Number of Medications in Shohada-ye Ashayer Hospital, Khorramabad. SJKU 2026; 30 (6) :77-87 URL: http://sjku.muk.ac.ir/article-1-8689-en.html
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