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The Effect of Sublingual Atropine on Clozapine-Induced Sialorrhea in Patients with Schizophrenia: A Triple-Blind Randomized Clinical Trial
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Narges Shams Alizadeh1    , Azad Maroufi2 , Marzieh Moghadam3 , Khaled Rahmani4 , Sima Sardari5 |
1- Associate professor, Department of psychiatry , Neurosciences Research Center, Sanandaj, Iran. & Kurdistan University of Medical Sciences, Sanandaj, Iran
2- 2. Associate professor, Department of psychiatry, Neurosciences Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran. & Kurdistan University of Medical Sciences, Sanandaj, Iran
3- 3. Assistant Professor, Department of psychiatry, Neurosciences Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran. & Kurdistan University of Medical Sciences, Sanandaj, Iran
4- 4. Associate professor, Department of Epidemiology and Biostatistics, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran. & Kurdistan University of Medical Sciences, Sanandaj, Iran
5- 5. Psychiatrist, Department of psychiatry and behavioral sciences, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran. & Kurdistan University of Medical Sciences, Sanandaj, Iran , simasardari25@gmail.com |
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Abstract: (632 Views) |
Abstract
Background and Aim: Clozapine is the most effective treatment for patients with treatment-resistant schizophrenia; however, sialorrhea is a common and distressing side effect associated with its use. This study aimed to evaluate the effect of sublingual atropine on clozapine-induced sialorrhea in patients with schizophrenia.
Methods: This was a randomized, triple-blind, placebo-controlled clinical trial involving 62 patients with schizophrenia. Patients were divided into two groups: the intervention group (1% sublingual atropine) and the control group (placebo). The severity and frequency of sialorrhea were assessed using the Drooling Rating Scale (DRS) and Visual Analog Scale (VAS) before the intervention and four weeks later. Data were analyzed using inferential statistical tests.
Results: Data from 57 patients were analyzed. In the atropine group, the mean severity (P<0.001) and frequency (P<0.001) of sialorrhea significantly decreased. In contrast, no significant changes were observed in the control group (P>0.05). Additionally, VAS scores in the atropine group showed a significant reduction after the intervention compared to baseline (P<0.001).
Conclusion: Sublingual atropine can reduce the severity and frequency of clozapine-induced sialorrhea. However, no significant differences were observed between the intervention and control groups. Further studies with larger sample sizes and more precise evaluations are recommended.
Keywords:
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| Keywords: Atropine, Sialorrhea, Clozapine, Schizophrenia |
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Full-Text [PDF 814 kb]
(22 Downloads)
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Type of Study: Original Research |
Subject:
Psychiatric
Received: 2024/05/29 | Accepted: 2025/05/17 | Published: 2026/07/25
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Research code: IRCT20221101056373N1 Ethics code: IR.MUK.REC.1401.226 Clinical trials code: IRCT20221101056373N1
Shams Alizadeh N, Maroufi A, Moghadam M, Rahmani K, Sardari S. The Effect of Sublingual Atropine on Clozapine-Induced Sialorrhea in Patients with Schizophrenia: A Triple-Blind Randomized Clinical Trial. SJKU 2026; 31 (1) :51-60 URL: http://sjku.muk.ac.ir/article-1-8445-en.html
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