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Association of Vitamin D Receptor Gene Polymorphisms with Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis
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Kimya Ghaderi1    , Abbas Aghaei2 , Arvin Shahmoradi1 , Shamsi Zare3 , Asaad Azarnezhad4 |
1- Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran
2- Social Determinants of Health Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
3- .Department of Obstetrics and Gynecology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
4- Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran , azarnezhad@gmail.com |
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Abstract: (236 Views) |
Background and Aim: Gestational diabetes mellitus (GDM) is a common pregnancy complication with increasing prevalence and adverse maternal and neonatal outcomes. Emerging evidence suggests that vitamin D and its receptor (VDR), including genetic variants of the VDR gene, may play a role in insulin resistance and susceptibility to GDM. This study aimed to summarize the available evidence regarding the association between vitamin D receptor (VDR) gene polymorphisms and gestational diabetes mellitus (GDM).
Materials and Methods: The PubMed, Web of Science, Embase, and Scopus databases were searched for relevant studies. A systematic review and meta-analysis were conducted to compare patients with gestational diabetes mellitus and healthy controls regarding the distribution of VDR gene polymorphisms using allelic, codominant, dominant, and recessive genetic models.
Results: A total of 12 eligible studies were included in the systematic review, of which six were included in the meta-analysis. The VDR BsmI (rs1544410 G>A) polymorphism showed a significant association with GDM under the dominant model (OR = 0.65, 95% CI: 0.416–1.038) and the recessive model (OR = 2.065, 95% CI: 1.034–4.122). The other polymorphisms did not show any significant association with GDM under any of the genetic models. Considerable heterogeneity was observed among studies investigating the association between VDR gene polymorphisms and GDM, with publication year and matching being the most common sources of heterogeneity.
Conclusion: The BsmI (rs1544410) polymorphism of the VDR gene may be associated with the risk of gestational diabetes mellitus. Future studies should be designed to include standardized data collection and matching for important confounding factors, such as body mass index, age, and ethnicity. |
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| Keywords: Gestational diabetes mellitus, Polymorphism, Vitamin D receptor gene |
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Full-Text [PDF 1156 kb]
(116 Downloads)
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Type of Study: Review |
Subject:
Molecular Medicine and Genetics
Received: 2024/04/15 | Accepted: 2026/09/1 | Published: 2026/09/5
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