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Fertility in Women with Inflammatory Bowel Disease
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Jalaleddin Naghshbandi1    , Homayoon Vahedi2 , Reza Malekzadeh3 , Asrin Babahajian4 |
1- Assistant Professor, Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran , drjalalnaghshbandi@gmail.com
2- Associate Professor, Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
3- Professor, Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
4- MSc of Anatomical Science, liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran. |
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Abstract: (375 Views) |
Background: The inflammatory bowel diseases (IBD) affect the young people of reproductive age. There is little knowledge about complications from IBD during pregnancy and delivery. Here we aimed to evaluate the possible IBD effects in Fertility and pregnancy.
Materials and Methods: This observational study was conducted on female IBD aged between 15 and 50 years who referred to GI clinic of Shariati Hospital from 2013-2017. Details on disease activity, prenatal complications, delivery and neonatal outcome were collected through medical report.
Results: Among 1156 enrolled patients, 87.2% had UC and 12.8% had CD. About 40.2% of women had children. There was a history of infertility in 54 (7.4%) of subjects. No significant relation was found between the type of inflammatory bowel disease and the fertility status (P=0.47). However, the infertility rate in patients with Crohn's disease (9.5%) was significantly higher than patients with ulcerative colitis (4%) (P = 0.006).
The low age of the diagnosis was associated with a reduction in fertility (having a child) (p<0.001 r = 0.30) and an increase in abortion (p<0.004 r = 0.80) in the study population.
Conclusion: Our results suggest that women with IBD should not be so worried about a negative impact of their disease, disease activity, or medications on their infertility life. Although having a comprehensive and interdisciplinary approach to managing their pregnancy could re-assure and minimizes the disease related complication of pregnancy.
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| Keywords: Inflammatory Bowel Disease, ulcerative colitis, Crohn's disease, Fertility, Pregnancy complications |
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Type of Study: Original Research |
Subject:
Internal Medicine
Received: 2023/07/8 | Accepted: 2024/06/15
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