|
Investigation of the Relationship between SEN Virus and Systemic Lupus Erythematosus
|
Mohammad Shayestehpour    1, Faezeh Ebneali2 , Elnaz Vatani2 , Ahmad Piroozmand3 , Batool Zamani4 , Kamal Esalatmanesh5 |
1- Assistant Professor, Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran , shayestehpour-m@kaums.ac.ir
2- Master's student, Department of Microbiology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, Iran.
3- Associate Professor, Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran
4- Professor, Autoimmune Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran
5- Professor, Autoimmune Disease Research Center, Kashan University of Medical Sciences, Kashan, Iran |
|
|
Abstract: (770 Views) |
Background and Aim: Systemic lupus erythematosus is an autoimmune disease that affects joints, skin, kidneys, blood cells, brain, heart and lungs. The main cause of this complex disease is still not well known, but researchers consider environmental factors such as virus contamination to be involved in the development of the disease. The present study was designed to investigate the relationship between the SEN virus and systemic lupus erythematosus.
Materials and Methods: This case-control study included 58 healthy individuals and 58 patients with systemic lupus erythematosus referring to the rheumatology clinic of Shahid Beheshti Hospital in 1401. Patients' data including age, gender, duration of disease, clinical manifestations and disease activity were collected. Serum samples were taken from the patients and after DNA extraction, nested-PCR test was performed to identify SEN virus and its common genotypes.
Results: SEN virus was detected in 26 healthy people and 37 patients with lupus erythematosus (P=0.031). In the lupus patients, 20 cases had genotype H, 11 had genotype D and 6 had both genotypes. In the healthy cases, 10 had genotype H, 9 had genotype D and 7 had both genotypes. SEN virus was found more frequently in the patients with active systemic lupus erythematosus than in the patients with quiescent disease (P<0.045). There was no statistical relationship between virus genotype and systemic lupus erythematosus (P=0.105). Also, there was no correlation between the presence of SEN virus and the clinical symptoms of the disease and also the duration of the disease.
Conclusion: The results of the present study showed that SEN virus is significantly more prevalent in the lupus patients than in the healthy subjects. Therefore, the hypothesis of a possible link between this virus and lupus erythematosus is raised. More studies are necessary to discover the role of this virus in the development of systemic lupus erythematosus or change in its clinical course.
|
|
| Keywords: Anellovirus, Autoimmunity, Systemic lupus erythematosus, SEN virus |
|
|
Full-Text [PDF 371 kb]
(204 Downloads)
|
Type of Study: Original Research |
Subject:
Microbiology
Received: 2023/06/13 | Accepted: 2023/10/10 | Published: 2024/07/10
|
|
|
|
|
|
|
| References |
1. Zhang L. A common mechanism links Epstein‐Barr virus infections and autoimmune diseases. J Med Virol. 2023;95(1):e28363. [ DOI:10.1002/jmv.28363] [ PMID] 2. Zamani B, Shayestehpour M, Esfahanian F, Akbari H. The study of factors associated with pregnancy outcomes in patients with systemic lupus erythematosus. BMC Res Notes. 2020;13(1):1-6. [ DOI:10.1186/s13104-020-05039-9] [ PMID] [ ] 3. Jiao H, Acar G, Robinson GA, Ciurtin C, Jury EC, Kalea AZ. Diet and Systemic Lupus Erythematosus (SLE): From Supplementation to Intervention. Int J Environ Res Public Health. 2022;19(19):11895. [ DOI:10.3390/ijerph191911895] [ PMID] [ ] 4. Liu JL, Woo JM, Parks CG, Costenbader KH, Jacobsen S, Bernatsky S. Systemic Lupus Erythematosus Risk: The Role of Environmental Factors. Rheum Dis Clin. 2022;48(4):827-43. [ DOI:10.1016/j.rdc.2022.06.005] [ PMID] 5. Zamani B, Moeini Taba S-M, Shayestehpour M. Systemic lupus erythematosus manifestation following COVID-19: a case report. J Med Case Rep. 2021;15(1):1-4. [ DOI:10.1186/s13256-020-02582-8] [ PMID] [ ] 6. Shayestehpour M, Zamani B. Systemic lupus erythematosus and varicella‐like rash following COVID‐19 in a previously healthy patient. J Med Virol. 2021;93(5):2599. [ DOI:10.1002/jmv.26838] [ PMID] [ ] 7. Jog NR, James JA. Epstein Barr virus and autoimmune responses in systemic lupus erythematosus. Front Immunol. 2021;11:623944. [ DOI:10.3389/fimmu.2020.623944] [ PMID] [ ] 8. Jia X, Gong L, Huang G, Zhang W. Review of correlation between human parvovirus B19 and autoimmune disease etiology. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2020;36(1):75-80. 9. Choo HMC, Cher WQ, Kwan YH, Fong WWS. Risk factors for cytomegalovirus disease in systemic lupus erythematosus (SLE): a systematic review. Adv Rheumatol. 2019;59. [ DOI:10.1186/s42358-019-0055-y] [ PMID] 10. Talotta R, Atzeni F, Laska MJ. Retroviruses in the pathogenesis of systemic lupus erythematosus: Are they potential therapeutic targets? Autoimmunity. 2020;53(4):177-91. [ DOI:10.1080/08916934.2020.1755962] [ PMID] 11. Sagir A, Kirschberg O, Heintges T, Erhardt A, Häussinger D. SEN virus infection. Rev Med Virol. 2004;14(3):141-8. [ DOI:10.1002/rmv.421] [ PMID] 12. Sharifi Z, Mahmoudian SM, Talebian A. The prevalence of SEN virus infection in blood donors in Iran. Arch Iran Med. 2008 Jul;11(4):423-6. 13. Bahabadinejad M, Bouzari M, Talebi A. Frequency of SEN Virus in Cervicitis and Cervical Cancers in Isfahan. JIMS. 2011;29(147):912. 14. Pirouzi A, Bahmani M, Feizabadi MM, Afkari R. Molecular characterization of Torque teno virus and SEN virus co-infection with HIV in patients from Southern Iran. Rev Soc Bras Med Trop. 2014;47:275-9. [ DOI:10.1590/0037-8682-0073-2014] [ PMID] 15. Karimi-Rastehkenari A, Bouzari M. High frequency of SEN virus infection in thalassemic patients and healthy blood donors in Iran. Virol J. 2010;7:1-7. [ DOI:10.1186/1743-422X-7-1] [ PMID] [ ] 16. Costa MRd, Costa IPd, Devalle S, Castro ARCMd, Freitas SZ. Prevalence and genetic diversity of torque teno virus in patients with systemic lupus erythematosus in a reference service in Mato Grosso do Sul. Rev Bras Reumatol. 2012;52:49-54. [ DOI:10.1590/S0482-50042012000100006] 17. Gergely Jr P, Pullmann R, Stancato C, Otvos Jr L, Koncz A, Blazsek A, et al. Increased prevalence of transfusion-transmitted virus and cross-reactivity with immunodominant epitopes of the HRES-1/p28 endogenous retroviral autoantigen in patients with systemic lupus erythematosus. Clin Immunol. 2005;116(2):124-34. [ DOI:10.1016/j.clim.2005.04.002] [ PMID] 18. Shibata M, Wang RY-H, Yoshiba M, Shih JW-K, Alter HJ, Mitamura K. The presence of a newly identified infectious agent (SEN virus) in patients with liver diseases and in blood donors in Japan. J Infect Dis. 2001;184(4):400-4. [ DOI:10.1086/322050] [ PMID] 19. Pirovano S, Sottini A, Bianchi V. Incidence of the SENV-A subtype in different cohorts of patients .Antivir Ther. 2000;5.
|
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
|
Shayestehpour M, ebneali F, Vatani E, Piroozmand A, Zamani B, Esalatmanesh K. Investigation of the Relationship between SEN Virus and Systemic Lupus Erythematosus. SJKU 2024; 29 (2) :38-46 URL: http://sjku.muk.ac.ir/article-1-7950-en.html
|
