[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Subscription::
Contact us::
Site Facilities::
Webmail::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Journal Citation Index

 

Citation Indices from GS

AllSince 2019
Citations93315718
h-index3827
i10-index246148

 

..
Central Library of Kurdistan University of Medical Sciences
AWT IMAGE
..
Vice-Chancellery for Research and Technology
AWT IMAGE
..
SCImago Journal & Country Rank
:: Scientific Journal of Kurdistan University of Medical Sciences- NO 4, 2024 -Articles In press ::
Back to the articles list Back to browse issues page
Association Between MLH1 (SNP: rs63749820C/T) Gene Polymorphism and the Risk of Breast Cancer in Northwest of Iran
Fatemeh Azimi , Sara Ghaffarian 1, Mehdi Haghi
1- , s.ghaffarian@azaruniv.ac.ir
Abstract:   (155 Views)
Background and Aim: According to the available statistics in 2020, breast cancer was the most common cancer in women. The protein encoded by the MLH1 gene is part of the mismatch repair (MMR) system. In this research, the association of rs63749820 C>T polymorphism of MLH1 gene with susceptibility to breast cancer was investigated in northwest Iran.
Materials and methods: This case-control study was conducted on 100 women with breast cancer and 100 healthy women with no history of cancer in 1st and 2nd degree relatives. Single nucleotide polymorphism was investigated by Tetra-ARMS PCR technique. The analysis of the resulting data was done using the online statistical program java stat and SPSS version 26 software.
Results: The frequency of TT, CC and TC genotypes in patients was 11.95%, 23.91% and 64.13% respectively, and their frequency in healthy subjects was 5.10%, 28.57% and 66.32% respectively. Statistical analysis showed no association of any of the genotypes with breast cancer. The frequency of C and T alleles in patients was 55.98% and 44.02% respectively. In the control population, the frequency of C and T alleles was 61.73% and 38.27%, respectively. Also, the results showed that two alleles T (P-value = 0.254) and C (P-value = 0.254) were not associated with breast cancer in northwest Iran.
conclusion: The findings of this study showed that there is no significant relationship between genotypic and allelic distribution of MLH1 gene polymorphism rs63749820 with increased risk of breast cancer and also the clinical characteristics of patients studied in northwest Iran. The relationship between the clinical characteristics of people with breast cancer including age, tumor grade, lymph involvement, involved side, tumor size, tumor type with the genotypic distribution of this SNP was not significant.
 
Keywords: breast cancer, single nucleotide polymorphism, association study, MLH1 gene
     
Type of Study: Original Research | Subject: Molecular Medicine and Genetics
Received: 2023/02/11 | Accepted: 2024/02/6
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA

Ethics code: IR.AZARUNIV.REC.1401.016


XML   Persian Abstract   Print



Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Back to the articles list Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
Persian site map - English site map - Created in 0.05 seconds with 45 queries by YEKTAWEB 4657