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:: Volume 29, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2024) ::
SJKU 2024, 29(1): 1-8 Back to browse issues page
Association between KRAS Gene rs61764370 Polymorphism and Risk of developing Hashimoto's Thyroiditis
Nasser Keikha1 , Mohsen Saravani 2
1- Infectious Diseases and Tropical Medicine Research Center, Research Institute of Cellular and Molecular Sciences in Infectious Diseases, Zahedan University of Medical Sciences, Zahedan, Iran
2- Department of Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran. , moh.saravani@gmail.com
Abstract:   (540 Views)
Background and Aim: Hashimoto's thyroiditis (HT) is the most common autoimmune thyroid disease, characterised by the destruction of the thyroid gland due to the production of autoantibodies against thyroid peroxidase and thyroglobulin. Studies have shown the interaction between some genetic changes in the cell and environmental factors as one of the risk factors for the occurrence of HT. The aim of the present study was to investigate the relationship between the rs61764370 polymorphism in the KRAS gene and the risk of development of HT.
Materials and Methods: 120 HT patients and 120 healthy controls who had been matched in regard to age and gender participated in this study. PCR-RFLP method was used to determine the genotypes.
Results: The frequency rates of AA, AC and CC genotypes were 87.5%, 8.5% and 6.7% in the control group, and 93.3%, 5.3% and 0.8% in the patient group respectively. Our results showed that the frequency of CC genotype was significantly higher in the control group than that in the patient group (P≤0.05).
Conclusion: Our results suggested the protective effect of the CC genotype and C allele of the rs61764370 polymorphism in the KRAS gene on the development of HT.
 
Keywords: Hashimoto's thyroiditis, KRAS, Polymorphism, Zahedan
Full-Text [PDF 386 kb]   (133 Downloads)    
Type of Study: Original Research | Subject: Biochemistry and Clinical Laboratory
Received: 2023/01/31 | Accepted: 2023/07/5 | Published: 2024/04/16
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Keikha N, Saravani M. Association between KRAS Gene rs61764370 Polymorphism and Risk of developing Hashimoto's Thyroiditis. SJKU 2024; 29 (1) :1-8
URL: http://sjku.muk.ac.ir/article-1-7793-en.html


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Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 29, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2024) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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