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Comparison of Postoperative Pain Intensity after Laparoscopic Cholecystectomy with Intraperitoneal Injection of Bupivacaine or Hydrocortisone alone Versus Bupivacaine with Morphine: A Clinical Trial
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Maryam Zahedi1    , Arazbardi Ghourchaei2 , Seyede Mahrokh Maddah3 , Roya Mousavi4 , Kazem Kazemnejad5 |
1- Assistant Professor, Department of Anesthesiology and Critical Care,5azar Hospital, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
2- Golestan University of Medical Sciences & Department of Anesthesiology and Critical Care, Taleghani Children's Hospital, School of Medicine, Golestan University of Medical Sciences, Gorgan, Iran.
3- Golestan University of Medical Sciences & Assistant Professor,Clinical Research Development Unit (CRDU),5azar Hospital, Golestan University of Medical Sciences, Gorgan, Iran
4- Golestan University of Medical Sciences & Assistant Professor,Clinical Research Development Unit (CRDU),5azar Hospital, Golestan University of Medical Sciences, Gorgan,Iran
5- Golestan University of Medical Sciences & Associate Professor,Clinical Research Development Unit (CRDU),5azar Hospital, Golestan University of Medical Sciences, Gorgan, Iran , kazemnejad1341@yahoo.com |
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Abstract: (1629 Views) |
Background and Aim: Laparoscopic cholecystectomy is used as a standard method for gallbladder resection due to less pain and bleeding than open surgery. This study was performed to evaluate and compare the severity of pain after laparoscopic cholecystectomy with the intraperitoneal injection of bupivacaine or hydrocortisone alone or bupivacaine with morphine in the 5th Azar educational hospital in Gorgan in 2015.
Materials and Methods: This randomized double-blind clinical trial study was performed on 60 patients undergoing laparoscopic cholecystectomy surgery. Patients were divided into 3 groups: A (30 cc of bupivacaine 0.25% intraperitoneal), B (30 cc of bupivacaine 0.25% with 2 mg morphine intraperitoneal), and C (200 mg hydrocortisone at 30 cc). The severity of pain and hemodynamic parameters were registered at specific times 30 minutes, 1, 4 hours after surgery. Data were analyzed using ANOVA, independent t-test, and chi-square in SPSS 18 software.
Results: Postoperative pain intensity was significantly higher in group C than in the other two groups (P <0.05). Group A showed less pain intensity in the first half-hour after surgery than group B, but in 1 and 4 hours after surgery, pain intensity was less reported in group B.
Conclusion: It seems that the combination of bupivacaine and morphine, during 1 to 4 hours after surgery, has a better effect on reducing pain in patients after laparoscopic cholecystectomy.
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| Keywords: Bupivacaine, Hydrocortisone, Morphine, Pain Intensity, Laparoscopic Cholecystectomy |
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Full-Text [PDF 540 kb]
(119 Downloads)
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Type of Study: Original Research |
Subject:
Medicine - General Surgery
Received: 2023/01/29 | Accepted: 2025/02/1 | Published: 2025/12/30
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