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:: Volume 27, Issue 6 (Scientific Journal of Kurdistan University of Medical Sciences 2023) ::
SJKU 2023, 27(6): 141-148 Back to browse issues page
Recurrent Membranous Nephropathy Management after Kidney Transplant: A Case Report
Mohammad saad Forghani1 , Hormat Rahimzadeh 2, Mahmoud Parvin3 , Anvar Mohammadi1
1- Assistant Professor, Department of Internal Medicine, Faculty of Medicine, Kurdestan University of Medical Sciences, Sanandaj, Iran
2- Assistant Professor, Department of Internal Medicine, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. , h-rahimzadeh@sina.tums.ac.ir
3- Associate Professor, Department of Pathology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:   (1680 Views)
Background and Aim: Membranous nephropathy (MN) is a podocytopathy characterized histologically by uniform thickening of the glomerular basement membrane due to the presence of subepithelial immune deposits. This disease can occur in a transplanted kidney as a recurrence of primary (Recurrent Membranous Nephropathy, RMN) or de novo disease.
Case report: A 40-year-old non-smoker man with a history of membranous nephropathy and resultant kidney failure, underwent a kidney biopsy 9 months after transplantation because of proteinuria of 4000 mg/day. Diagnosis of recurrence of membranous nephropathy in the transplanted kidney was made. The patient was given two doses of rituximab 1000 mg at a 15 day interval. Gradually, the amount of proteinuria decreased to 188 mg/day after 4 months, and his kidney function remained stable (creatinine 0.8 mg/dl) during the treatment.
Conclusion:  Membranous nephropathy can recur after kidney transplantation, and in cases of proteinuria more than one gram per day, we can use rituximab.

Keywords: Membranous nephropathy, Kidney transplant, Rituximab, Recurrence.
Full-Text [PDF 963 kb]   (542 Downloads)    
Type of Study: case report | Subject: Internal Medicine
Received: 2022/09/30 | Accepted: 2022/12/14 | Published: 2023/03/3
References
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forghani M S, Rahimzadeh H, Parvin M, mohammadi A. Recurrent Membranous Nephropathy Management after Kidney Transplant: A Case Report. SJKU 2023; 27 (6) :141-148
URL: http://sjku.muk.ac.ir/article-1-7592-en.html


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Volume 27, Issue 6 (Scientific Journal of Kurdistan University of Medical Sciences 2023) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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