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Recurrent Membranous Nephropathy Management after Kidney Transplant: A Case Report
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Mohammad saad Forghani1    , Hormat Rahimzadeh *2 , Mahmoud Parvin3 , Anvar Mohammadi1 |
1- Assistant Professor, Department of Internal Medicine, Faculty of Medicine, Kurdestan University of Medical Sciences, Sanandaj, Iran
2- Assistant Professor, Department of Internal Medicine, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. , h-rahimzadeh@sina.tums.ac.ir
3- Associate Professor, Department of Pathology, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran |
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Abstract: (5030 Views) |
Background and Aim: Membranous nephropathy (MN) is a podocytopathy characterized histologically by uniform thickening of the glomerular basement membrane due to the presence of subepithelial immune deposits. This disease can occur in a transplanted kidney as a recurrence of primary (Recurrent Membranous Nephropathy, RMN) or de novo disease.
Case report: A 40-year-old non-smoker man with a history of membranous nephropathy and resultant kidney failure, underwent a kidney biopsy 9 months after transplantation because of proteinuria of 4000 mg/day. Diagnosis of recurrence of membranous nephropathy in the transplanted kidney was made. The patient was given two doses of rituximab 1000 mg at a 15 day interval. Gradually, the amount of proteinuria decreased to 188 mg/day after 4 months, and his kidney function remained stable (creatinine 0.8 mg/dl) during the treatment.
Conclusion: Membranous nephropathy can recur after kidney transplantation, and in cases of proteinuria more than one gram per day, we can use rituximab.
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| Keywords: Membranous nephropathy, Kidney transplant, Rituximab, Recurrence. |
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Full-Text [PDF 963 kb]
(1569 Downloads)
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Type of Study: case report |
Subject:
Internal Medicine
Received: 2022/09/30 | Accepted: 2022/12/14 | Published: 2023/03/3
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