Abstract Background and purpose: Due to many students, staff and faculties as well as various educational and research departments in university environments, providing a safe and risk-free environment is one of the main challenges in universities and higher education centres. The purpose of this study is a comprehensive and detailed assessment of risks in different departments of Kurdistan University of Medical Sciences. Material and Method: A descriptive-analytical study was conducted on buildings, laboratories, motor homes, libraries and transit routes at Kurdistan University of Medical Sciences. Fire risk assessment was performed with FRAME software in three areas of assets, people and activities. The safety status of laboratories was assessed by ACHiL specific method. Failures in buildings, motor home installations, electrical panels and equipment were identified and evaluated by the FMEA method. The safety level of traffic and transportation routes, parking lots, passages and streets of the complex was assessed by the ET&BA method. Results: The fire risk for assets and activities in all floors of colleges was unfavourable (above one) and also the fire risk for people in most colleges were assessed as unfavourable. In the laboratory, the dangers of chemicals such as cylinders under the pressure of neutral and oxidizing gases, corrosive substances and toxic solutions were most severe. In buildings, the highest risk priority was related to failures in the emergency plan, non-standard height of stair railings and low width of stairs. Also, in motor homes, most failures were related to fuel tanks (leakage of connections and drain valves) and hot boilers (excessive heat and pressure). The electrical safety status was assessed as unsuitable due to failures in the protection systems (grounding system and life-saving switch). Chemical energy and potential were among the most important energies damaging the paths and passages. Conclusion: The study showed unfavourable safety status and warning conditions in most sections and activities. Awareness of the safety situation can help universities and academic institutions develop an effective risk management program.