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:: Volume 28, Issue 6 (Scientific Journal of Kurdistan University of Medical Sciences 2024) ::
SJKU 2024, 28(6): 48-64 Back to browse issues page
Comparison of the Consequences of Intratracheal Administration of Surfactant Plus Budesonide with Surfactant alone in Preterm Infants with Respiratory Distress Syndrome
Morteza Habibi1 , Fatemeh Toohidinia2
1- Children Growth Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran.
2- Children Growth Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran. , dr.fatemetoohidnia@gmail.com
Abstract:   (1170 Views)
Background and Aim: To control complications in infants with respiratory distress syndrome, surfactants and auxiliary drugs such as budesonide are used to reduce the inflammatory reactions of the airways. The aim of this study is to compare the effect of intratracheal administration of survanta and survanta with budesonide in premature infants with respiratory distress syndrome.
Materials and Methods: This clinical trial included 50 premature infants with respiratory distress syndrome, hospitalized in the neonatal intensive care unit in Qazvin Children's Hospital, in 2019. The patients were divided into two groups. One group (25 cases) received intratracheal survanta (1 milliliter) + budesonide (0.25 milligram) and the other group (25 cases) received only intratracheal survanta. Using SPSS 21 software, data were analyzed by  descriptive statistics, Fisher's exact and T-test (p<0.05).
Results: In the survanta+budesonide group, we found intraventricular hemorrhage in 50% and also death in 50% of the cases. In the pregnant women over 31 years of age and female infants receiving survanta + budesonide, no complications were seen. The effect of Survanta + budesonide compared to survanta on reducing complications in the infants (p = 0.048), in regard to the mothers' age group; 31 years and under 31 years (p = 0.049), and over 31 years of age (p = 0.046), female (p=0.047) and male (p=0.050) showed  significant differences.
Conclusion: Administering survanta with budesonide resulted in better efficacy and fewer side effects. Budesonide can be used as an adjuvant treatment. Appropriate therapeutic measures are important for the improvement and survival of the newborns with respiratory distress syndrome.
Keywords: Surfactant, Surfactant with budesonide, Premature infants, Respiratory distress syndrome
Full-Text [PDF 675 kb]   (451 Downloads)    
Type of Study: Original Research | Subject: Medicine - Pediatric
Received: 2022/05/8 | Accepted: 2023/09/5 | Published: 2024/02/6
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Ethics code: IR.QUMS.REC.1399.386
Clinical trials code: IRCT20210412050944N1



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Habibi M, Toohidinia F. Comparison of the Consequences of Intratracheal Administration of Surfactant Plus Budesonide with Surfactant alone in Preterm Infants with Respiratory Distress Syndrome. SJKU 2024; 28 (6) :48-64
URL: http://sjku.muk.ac.ir/article-1-7342-en.html


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Volume 28, Issue 6 (Scientific Journal of Kurdistan University of Medical Sciences 2024) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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