Investigating the effects of dihydroxyacetone on oxidative stress factors and histology of heart and liver tissue in acute aluminum phosphide poisoning

ahmadi, jafar; Jafari, Elham; Heidari, Mahmoud Reza; Eskandari, Mahsa; Yousefi, Fatemeh; Karami Mohajeri, Somayeh

doi:10.61186/sjku.28.1.40

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Central Library of Kurdistan University of Medical Sciences

Vice-Chancellery for Research and Technology

Volume 28, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2023)

SJKU 2023, 28(1): 40-54

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Investigating the effects of dihydroxyacetone on oxidative stress factors and histology of heart and liver tissue in acute aluminum phosphide poisoning

Jafar Ahmadi¹

, Elham Jafari²

, Mahmoud Reza Heidari³

, Mahsa Eskandari⁴

, Fatemeh Yousefi⁵

, Somayeh Karami Mohajeri⁶

1- Pharmaceutics Research Center, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
2- Associate Professor, Department of Pathology, Pathology and Stem Cells Research Center, Kerman University of Medical Science, Kerman, Iran
3- Professor, Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
4- Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
5- Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran.
6- Assistant Professor, Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran , s_karami@kmu.ac.ir

Abstract: (1408 Views)

Background and Aim: Aluminum phosphide poisoning has a high mortality rate because of the production of phosphine gas and refractory hypotension. Based on the effect of dihydroxyacetone on the treatment of hypotension and reduction of cytochrome C oxidase, the effects of dihydroxyacetone on the level of oxidative stress factors and histology of heart and liver tissue in aluminum phosphide-poisoned male rats were investigated.
Materials and Methods: In this study, 24 rats were randomly divided into 4 groups including control (corn oil), aluminum phosphide (15 mg/kg), dihydroxyacetone (50 mg/kg) and also poisoned and treated group (aluminum phosphide (15 mg/kg) + dihydroxyacetone (50 mg/kg)). After 24 hours, the animals were sacrificed and the blood, plasma, heart, and liver samples were collected then oxidative stress factors and histology of the heart and liver were investigated.
Results: Aluminum phosphide poisoning increased lipid peroxidation in red blood cells (p=0.001) and liver tissue (p=0.023) and also increased protein carbonylation in plasma (p =0.005) and red blood cells (p=0.001). After administration of dihydroxyacetone, lipid peroxidation in red blood cells (p=0.001) and liver (p=0.001) and carbonylation of proteins in red blood cells (p=0.003) and plasma (p=0.019) decreased. No significant change was observed in total plasma antioxidant capacity, carbonylation levels of the liver and heart, and lipid peroxidation in heart tissue. In addition, treatment with dihydroxyacetone significantly improved the histological changes in liver and heart tissue.
Conclusion: Dihydroxyacetone not only prevents phosphine-induced deaths but also improves oxidative stress and histology of liver and heart tissue.

Keywords: Rice table, Phosphine, Fumigant, cytochrome c oxidase, Dihydroxyacetone

Full-Text [PDF 868 kb] (621 Downloads)

Type of Study: Original Research | Subject: Pharmacology
Received: 2021/06/23 | Accepted: 2021/11/14 | Published: 2023/03/15

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45. Zamani N, Mehrpour O. Protective role of G6PD deficiency in poisoning by aluminum phosphide; are there possible new treatments? Eur Rev Med Pharmacol Sci. 2013;17(7):994-995. PMID: 23640450. Available from: https://pubmed.ncbi.nlm.nih.gov/23640450.

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62. Anand R, Kumari P, Kaushal A, Bal A, Wani WY, Sunkaria A, et al. Effect of acute aluminum phosphide exposure on rats-A biochemical and histological correlation. Toxicol Lett. 2012;215(1):62-69. Available from: https://www.sciencedirect.com/science/article/pii/S0378427412013252. doi: 10.1016/j.toxlet.2012.09.020. [DOI:10.1016/j.toxlet.2012.09.020] [PMID]

63. Gouda AS, El-Nabarawy NA, Ibrahim SF. Moringa oleifera extract (Lam) attenuates Aluminium phosphide-induced acute cardiac toxicity in rats. Toxicol Rep. 2018;5:209-212. Available from: https://www.sciencedirect.com/science/article/pii/S2214750018300155. doi: 10.1016/j.toxrep.2018.01.001. [DOI:10.1016/j.toxrep.2018.01.001] [PMID] []

64. Mehrpour O, Jafarzadeh M, Abdollahi M. A Systematic Review of Aluminium Phosphide Poisoning. Archives of Industrial Hygiene and Toxicology. 2012;63(1):61. Available from: https://hrcak.srce.hr/78648. doi: 10.2478/10004-1254-63-2012-2182. [DOI:10.2478/10004-1254-63-2012-2182] [PMID]

65. Anand R, Sharma D, Verma D, Bhalla A, Gill K, Singh S. Mitochondrial electron transport chain complexes, catalase and markers of oxidative stress in platelets of patients with severe aluminum phosphide poisoning. Hum Exp Toxicol. 2013;32(8):807-816. Available from: https://journals.sagepub.com/doi/full/10.1177/0960327112468909. doi: 10.1177/0960327112468909. [DOI:10.1177/0960327112468909] [PMID]

66. Akhtar S, Rehman A, Bano S, Haque A. Accidental phosphine gas poisoning with fatal myocardial dysfunction in two families. 2015;25(5):378-379. Available from: https://pubmed.ncbi.nlm.nih.gov/26008669.

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ahmadi J, Jafari E, Heidari M R, Eskandari M, Yousefi F, Karami Mohajeri S. Investigating the effects of dihydroxyacetone on oxidative stress factors and histology of heart and liver tissue in acute aluminum phosphide poisoning. SJKU 2023; 28 (1) :40-54
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Volume 28, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2023)

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مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences

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