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Case Report: Agenesis of Corpus Callousum
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| Soheila Reshadat |
| , soheyla.reshadat151@gmail.com |
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Abstract: (29653 Views) |
| ABSTRACT
Background and Aim: Corpus callosum is the biggest comisure of interventricula. The main etiology of agenesis of corpus callousum is the failure of programmed cellular death. This disease comprises a heterogenic group of disorders which has a wide range of presentations from medical and neurological symptoms to asymptomatic patients with normal intelligence. Diagnosis of this disease can be made by use of CT and MRI. The disease can be transmitted via autosomal dominant or X-linked genes and can be associated with chromosomal disorders such as trisomy of 8 and 18 and different metabolic disorders. There is no standard therapy for this disorder. Prognoses of the patients are variable and usually the disorder does not lead to death.
Case report: The patient was admitted, for the first time, to the hospital when he was 3 day old because his mother had a sonography at the 28th week of pregnancy which was compatible with a cyst in the brain of her fetus. After delivery the parents of the patient referred to the pediatric clinic for further evaluation of their neonate. After examination of the patient and paraclinical studies, the patient was diagnosed as a case of agenesis of corpus callousum. Neurological examination of the patients was within normal limits. The growth indices of the patient were normal and there was no evidence of any neurological, metabolic or chromosomal disorders on clinical and paraclinical grounds.
Conclusion: Agenesis of corpus callosum is a rare disorder which can be associated with hypotonia, seizure, hydrocephalus, acidosis, hypoglycemia, hepatomegaly, increased serum ammonia, chromosomal disorders and ophthalmologic diseases such as cataract, optic nerve atrophy and … . But no evidence of any above- mentioned disorders was found in our patient on clinical and paraclincal grounds, which indicates a wide range of clinical signs and symptoms in this disorder.
Key words: Corpus callousum, Metabolic disorders.
Conflict of Interest: Nill
Received: November 21, 2007 Accepted: May 22, 2008 |
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| Keywords: Corpus callousum, Metabolic disorders. |
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Full-Text [PDF 1907 kb]
(3131 Downloads)
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Type of Study: Original Research |
Subject:
General
Received: 2009/04/11 | Published: 2008/09/15
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