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:: Volume 28, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2023) ::
SJKU 2023, 28(1): 20-29 Back to browse issues page
Evaluation of the Antifungal Effect of Fluconazole Separately and with Coriander Essential Oil on Candida Species Isolated from the Mouth of HIV-Positive Individuals
Vida Abdi1 , Parvin Dehghan 2, Behzad Zolfaghari3 , Mehrnoush Maheronnaghsh4 , Asghar Heidarian5
1- MSc student, Department of Mycology and Parasitology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
2- Associate Professor, Department of Mycology and Parasitology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran , dehghan@med.mui.ac.ir
3- Professor, Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.
4- Assistant Professor, Department of Mycology and Parasitology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
5- Staff, Isfahan Health Center , Isfahan University of Medical Sciences, Isfahan, Iran
Abstract:   (558 Views)
Background and Aim: Candida species are opportunistic yeasts that can cause opportunistic infections when the host becomes debilitated or immunocompromised. Coriander is a plant belonging to the Umbelliferae family and its leaves and seeds are widely used in traditional medicine. Coriander essential oil (E.O.) has shown antibacterial, antifungal, and antioxidant activities. This study aimed to evaluate the antifungal effect of fluconazole alone and with coriander E.O on 39 Candida species isolated from the mouth of Human Immunodeficiency Virus (HIV) positive individuals.
Materials and Methods: In this study, the broth microdilution tests according to the CLSI M27-S3 were applied to find the amount of Minimum inhibitory concentration (MIC) of fluconazole alone and together with coriander E.O (synergism) for each Candida isolate. For this purpose, the E.O. of Coriander seeds was extracted using a Clevenger apparatus by steam hydro-distillation, and then the synergism effect of E.O. and fluconazole on Candida isolates was investigated. Data were analyzed by SPSS-25 software. Mann-Whitney, and Tukey post hoc tests, and the one-way analysis of variance were used to analyze the results.
Results: Susceptibility of fluconazole was determined as follows: 69.2% of the Candida isolates were sensitive, 17.9% were resistant and 12.9% were susceptible dose-dependent (SDD). The MIC mean was 27.3 μg/ml for fluconazole, 32.7 μg/ml for coriander E.O, and 9.39 μg/ml for the combined effect of fluconazole and Coriander E.O (synergistic effects).
Conclusion: The fact that Coriander E.O has an inhibitory effect on all Candida isolates used in this study, it can be considered a capable antifungal, especially in combination with fluconazole (synergistic effects), and the antifungal effect of Coriander E.O is proposed to investigate in treating candidiasis for future clinical trials.
Keywords: Candida species, AIDS, Coriander, Antimicrobial, Fluconazole.
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Type of Study: Applicable | Subject: Parasitology and Mycology
Received: 2021/04/13 | Accepted: 2021/10/20 | Published: 2023/03/15
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Abdi V, Dehghan P, Zolfaghari B, Maheronnaghsh M, Heidarian A. Evaluation of the Antifungal Effect of Fluconazole Separately and with Coriander Essential Oil on Candida Species Isolated from the Mouth of HIV-Positive Individuals. SJKU 2023; 28 (1) :20-29
URL: http://sjku.muk.ac.ir/article-1-6681-en.html


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Volume 28, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2023) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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