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Effects of Anethum tablet and Hydroalcoholic Extract of Anethum graveolens on Oxidative Stress in Hippocampus of Hypercholesterolemic Rats
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Ebrahim Abbasi1    , Fatemeh Mirzaei2 , Ali Nikkhah3 , Heidar Tayebinia4 , Mohammad taghi Goodarzi4 , Alireza Komaki5 , Iraj Khodadadi6 |
1- . Associate Professor, Department of Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
2- . Assistant professor, Department of Anatomical Sciences, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
3- Medical Student, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
4- Professor, Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.
5- Professor, Department of Physiology, School of Medicine, Neurophysiology Research Center, Neuroscience and Mental Health Research Institute, Avicenna Health Research Institute, Hamadan University of Medical Sciences, Hamadan, Iran.
6- . Professor, Department of Clinical Biochemistry, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran., , ikhodadadi@yahoo.com |
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Abstract: (701 Views) |
Background and Aim: A high-cholesterol diet can damage the hippocampus, thus increasing oxidative stress and ultimately reducing memory and learning. Therefore, this study aimed to investigate the effect of Anethum tablets and Anethum extract on memory, and antioxidant status, in hypercholesterolemic rats.
Materials and Methods: In this experiment, 36 male Wistar rats were randomly divided into 6 groups (6/group): group 1; control, 2- hypercholesterolemic, 3- control+ 300 mg/kg Anethum tablet, 4- hypercholesterolemic + 300 mg/kg Anethum extract, 5- control + 300 mg/kg Anethum tablet, 6- hypercholesterolemic + 300 mg/kg Anethum extract. Two months after drug administration, the memory test was performed. The malondialdehyde level (MDA), total antioxidant capacity (TAC), and total oxidant status (TOS) were measured. Histological changes were also investigated.
Results: Treatment with Anethum tablets and Anethum extract significantly reduced MDA and TOS levels (p<0.05). Anethum treatment also increased TAC and glutathione levels (p <0.05). Histological results showed that the Anethum improved morphological changes.
Conclusion: Anethum tablets and Anethum extract reduced oxidative stress in the hippocampus. This study shows that the effects of Anethum tablets and dill extract are similar. |
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| Keywords: Anethum extract, Antioxidant, Cholesterol, Malondialdehyde |
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Full-Text [PDF 3051 kb]
(91 Downloads)
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Type of Study: Original Research |
Subject:
Biochemistry and Clinical Laboratory
Received: 2021/01/31 | Accepted: 2026/02/2 | Published: 2026/07/12
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Research code: 950304946 Ethics code: IR.UMSHA. REC 1395. 25
Abbasi E, mirzaei F, nikkhah A, tayebinia H, goodarzi M T, komaki A et al . Effects of Anethum tablet and Hydroalcoholic Extract of Anethum graveolens on Oxidative Stress in Hippocampus of Hypercholesterolemic Rats. SJKU 2026; 30 (6) :1-10 URL: http://sjku.muk.ac.ir/article-1-6578-en.html
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