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:: Volume 25, Issue 3 (Scientific Journal of Kurdistan University of Medical Sciences 2020) ::
SJKU 2020, 25(3): 99-105 Back to browse issues page
The protective Effect of Nigella sativa on sperm parameter in mice treated with dexamethasone
Saeid Miri1 , Morteza Abouzaripour2 , Mohammad Jafar Rezaie3 , Fardin Fathi2 , Bahram Nikkho4 , Daem Roshani5 , Shiva Khalesro6 , Erfan Daneshi 7
1- Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
2- Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
3- Department of anatomical sciences, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
4- Department of pathology, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
5- Department of Epidemiology and Biostatistics , School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
6- Agronomy and plant breeding, department faculty of agriculture university of Kurdisan, Sanandaj, Iran
7- Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran , erfan.daneshi@yahoo.com
Abstract:   (315 Views)
Background and Aim: Dexamethasone affects testis hemostasis through reduction of  testosterone level . In one study dexamethasone induced spermatogenesis defects through epithelial vacuolizations and sloughing of germ cell layer.
Material and Methods: Forty NMRI mice were randomly divided into four groups. Control and dexamethasone groups received normal saline and dexamethasone (5 mg/kg) respectively for 7 days. Dexamethasone and Nigella sativa(NS) (5 mg/kg) were given to the third group and the fourth group(Nigella sativa group) received 5 mg/kg  Nigella sativa for 7 days. Epididymal sperm parameters were used for evaluation of the effects of dexamethasone and Nigella sativa on testis.  
Results: Epididymal sperm parameters) count,motility and abnormal sperm) showed significant alterations in dexamethasone group (p<0.05). Treatment with NS+ dexamethasone significantly prevented these changes (p<0.05).
Conclusion:Numerous studies have been performed to evaluate destructive effects of dexamethasone on  male reproductive system. The aim of this study was to assess protective effect of Nigella sativa against the side effects of dexamethasone on male reproductive system. We found that dexamethasone could decrease sperm parameters. These changes were reduced by using Nigella sativa.
Keywords: Nigella sativa, Dexamethasone, Sperm parameters
Full-Text [PDF 233 kb]   (79 Downloads)    
Type of Study: Research | Subject: General
Received: 2019/09/24 | Accepted: 2020/01/18 | Published: 2020/07/22
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miri S, abouzaripour M, Rezaie M J, Fathi F, nikkho B, roshani D, et al . The protective Effect of Nigella sativa on sperm parameter in mice treated with dexamethasone. SJKU. 2020; 25 (3) :99-105
URL: http://sjku.muk.ac.ir/article-1-5393-en.html


Volume 25, Issue 3 (Scientific Journal of Kurdistan University of Medical Sciences 2020) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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