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:: Volume 25, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2020) ::
SJKU 2020, 25(2): 54-60 Back to browse issues page
Effect of Chronic Nicotine Administration on the Pro-oxidant Antioxidant Balance of Mice Serum: Role of Rosmarinic Acid
Naim Sharafi ahvazi1 , Erfan Daneshi Dr2 , Bahram Nikkhoo Dr3 , Daem Roshani Dr4 , Mohammad jafar Rezaie Dr5 , Hamid reza Asgari Dr6 , Morteza Abouzaripour Dr 7
1- Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
2- Department of Anatomy, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
3- Department of Pathology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
4- Social Determinants of Health Kurdistan Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
5- Department of Anatomy, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran.
6- Department of Anatomy, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
7- Department of Anatomy, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran , m.abouzary@gmail.com
Abstract:   (126 Views)
Background and Aim: In this experimental study, nicotine has been recognized to result in oxidative stress by inducing the generation of reactive oxygen species. The current research was designed to investigate the protective effect of rosmarinic acid, a radical scavenger and antioxidant, on Pro oxidant anti-oxidant balance of serum in nicotine treated mice.
Materials and Methods: Thirty-six mature male NMRI mice were divided into 6groups: (two controls, two nicotine-treated [0.5 mg/kg], and two nicotine plus rosmarinic acid [10 mg/kg]) were used in this study and treated for 15 and 30days respectively. The standard protocol was used to measure pro-oxidant-antioxidant balance, superoxide dismutase, and serum Catalase.
Results: As compared to control group (90±3.03315 HK), the 15-day results, in nicotine-treated group (100±5.17687 HK) there was a significant increase in the serum PAB ratio. Similarly, for samples of the day 30, there was a significant increase in the serum PAB ratio of nicotine-treated group (106±3.52136 HK) versus control group (87±1.32916 HK) (P≤0.05). SOD of 15(1.21±1.12) and 30 days (1.89±0.26) treated groups, showed significant decreased versus control groups (2.90±0.09), (2.82±0.08) respectively (P≤0.05).  
Catalase of 15(12.13±2.30) and 30 days (11.57±1.42) treated groups, showed significant decreased versus control groups (25.12±2.21), (24.1±1.29) respectively (P≤0.05).
Conclusion: These results indicate that rosmarinic acid improves the level of antioxidant enzymes and modifies pro-oxidant-antioxidant imbalance
Keywords: Antioxidants, Rosmarinus, Nicotine, Serum
Full-Text [PDF 304 kb]   (16 Downloads)    
Type of Study: Applicable | Subject: General
Received: 2019/05/18 | Accepted: 2020/01/19
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Sharafi ahvazi N, Daneshi E, nikkhoo B, Roshani D, Rezaie M J, Asgari H R et al . Effect of Chronic Nicotine Administration on the Pro-oxidant Antioxidant Balance of Mice Serum: Role of Rosmarinic Acid. SJKU. 2020; 25 (2) :54-60
URL: http://sjku.muk.ac.ir/article-1-5025-en.html


Volume 25, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2020) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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