[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Subscription::
Contact us::
Site Facilities::
Webmail::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Journal Citation Index

 

Citation Indices from GS

AllSince 2019
Citations95875914
h-index3928
i10-index251153

 

..
Central Library of Kurdistan University of Medical Sciences
AWT IMAGE
..
Vice-Chancellery for Research and Technology
AWT IMAGE
..
SCImago Journal & Country Rank
:: Volume 24, Issue 6 (Scientific Journal of Kurdistan University of Medical Sciences 2020) ::
SJKU 2020, 24(6): 79-92 Back to browse issues page
The effect of GABAB receptors in CA1 region of hippocampus on morphine tolerance in female Wistar race rats by conditioned place preference
Firoozeh Alavian 1, Saeedeh Ghiasvand2
1- Department of Basic Sciences, Farhangian University, Tehran, Iran , alavian.firoozeh@gmail.com
2- Department of Basic Sciences, Malayer University, Malayer, Iran.
Abstract:   (2755 Views)
Background and Aim: The hippocampus is a region of the brain that plays an important role in learning activities, including conditioned place preference (CPP). This area is widely used as the target of the studies on the reinforcing effects of the drugs and narcotics. Considering the wide distribution of GABAB receptors in the hippocampus CA1 region, these receptors are likely to play an important role in drug reward learning.
Materials and Methods: Wistar female rats were divided into 17 groups (N=7). Different amounts of morphine (0.5, 2.5, 5, 7.5, and 10 mg/kg) were injected subcutaneously to determine the effective dose of morphine. 3 days before induction of conditioned place preference, the animals received morphine injection (12.5 mg/kg) in order to induce tolerance. Then, baclofen as a stimulant (agonist) of GABAB receptors; and also, CGP35348 as an inhibitor of these receptors (antagonists) were injected into the CA1 region of the hippocampus.
Results: 5 mg/kg of morphine was considered as the effective dose at the significance level of P< 0.001. Baclofen at the doses of 6 mg/kg and 1/5 mg/kg increased tolerance to morphine (P <0.01 and P <0.05 respectively). CGP35348 at a dose of 6 mg/kg significantly reduced morphine tolerance (P <0.05).
Conclusion: The results of this study confirmed the importance of GABAB receptors in the CA1 region of the hippocampus in morphine tolerance in female rats.
Keywords: Rat, GABAB, Morphine, Tolerance
Full-Text [PDF 1343 kb]   (1800 Downloads)    
Type of Study: Original Research | Subject: General
Received: 2019/04/2 | Accepted: 2020/02/4 | Published: 2020/01/22
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Alavian F, Ghiasvand S. The effect of GABAB receptors in CA1 region of hippocampus on morphine tolerance in female Wistar race rats by conditioned place preference. SJKU 2020; 24 (6) :79-92
URL: http://sjku.muk.ac.ir/article-1-4897-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 24, Issue 6 (Scientific Journal of Kurdistan University of Medical Sciences 2020) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
Persian site map - English site map - Created in 0.05 seconds with 45 queries by YEKTAWEB 4660