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Effects of White Button Mushroom Powder on Anthropometric Indices, Blood Pressure and Liver Enzymes in Type 2 Diabetic Patients: A Double-Blind, Randomized, Placebo-Controlled Trial
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Hadiseh Hashemi yusefabad    1, Reza Sohrabi kabi2 , Maryam Asadi3 , Seyedahmad Hosseini4 , Mahtab Abdi5 , Mehrnoosh Zakerkish6 , Bahman Cheraghian7 |
1- Department of Nutritional Sciences, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran , hashemihadis@yahoo.com
2- Clinical Research Development Center of Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
3- Nutrition and Metabolic Diseases Research Centre, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
4- Department of Nutritional Sciences, School of Paramedical Sciences, Nutrition and Metabolic Disease Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
5- Department of microbiology, school of medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
6- Department of Internal Medicine, School of Medicine, Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
7- Department of Biostatistics and Epidemiology, School of Health, Alimentary Tract Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran |
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Abstract: (2175 Views) |
Background and Aim: Diabetes mellitus (DM) is one of the most common metabolic disorders characterized by chronic hyperglycemia with impaired metabolism of carbohydrate, fat, and protein. The purpose of this study was to evaluate the effects of white button mushroom (WBM) powder on anthropometric indices, blood pressure, and liver enzymes in type 2 diabetic patients (T2DM).
Materials and Methods: This double-blind clinical trial included 41 T2DM patients between 23 and 50 years of age. Patients were randomly divided into intervention (n = 19 mushroom powder) and placebo (n = 22 corn starch) groups. Patients received 16 g dried WBM powder or corn starch/day for 8 weeks. Anthropometric indices, blood pressure, and liver enzymes were assessed at the baseline and at the end of our study. An independent sample t-test was used to compare quantitative variables between the two groups. Comparison of the mean values before and after treatment in each group was performed by means of paired T-test. p<0.05 was considered significant.
Results: Comparison of the results at the baseline and after 8 weeks showed no significant difference in regard to weight, body mass index, waist circumference, waist-to-hip ratio, and the waist-to-height ratio between the two groups (P > 0.05). However, the patients in the intervention group had a significant decrease in waist circumference and also lower weight at the end of the study compared to the baseline (P < 0.05). In addition, BMI reduction was significantly higher in the intervention group than in the control group (P < 0.05). There were no significant differences between the two groups in relation to hepatic enzymes, systolic and diastolic blood pressure at the end of the study (P > 0.05).
Conclusion: This study showed that WBM had no significant effect on liver protection. However, improvement in anthropometric indices in the intervention group indicated the potential effect of WBM on reducing T2DM complications. |
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| Keywords: Type 2 diabetes, White button mushroom, Obesity, Hepatic enzymes |
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Full-Text [PDF 507 kb]
(801 Downloads)
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Type of Study: Original Research |
Subject:
General
Received: 2019/02/20 | Accepted: 2020/12/12 | Published: 2021/07/23
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hashemi yusefabad H, sohrabi kabi R, asadi M, hosseini S, Abdi M, Zakerkish M et al . Effects of White Button Mushroom Powder on Anthropometric Indices, Blood Pressure and Liver Enzymes in Type 2 Diabetic Patients: A Double-Blind, Randomized, Placebo-Controlled Trial. SJKU 2021; 26 (3) :25-36 URL: http://sjku.muk.ac.ir/article-1-4817-en.html
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