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:: Volume 25, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2020) ::
SJKU 2020, 25(1): 1-11 Back to browse issues page
Investigating the Protective Effect of an Interval Training on Neutrophilic Factors of BDNF and CDNF in Rats Fed with High-fat Foods
Mohammad reza Asad1 , Soroor Hedayatnejad2 , Ali Barzegari 3, Mahbobeh Gholizadeh ahangari2
1- Department of physical education and sport, Payame Noor University, Tehran, Iran.
2- Department of physical education and sport, Payame Noor University, Tehran, Iran
3- Department of physical education and sport, Payame Noor University, Tehran, Iran , ali_barzegari@pnu.ac.ir
Abstract:   (645 Views)
Background and Aim: Exercise targets the secretion of brain-derived neurotrophic factors and has a major impact on the overall health of the brain. The present study aimed to investigate the protective effect of a period of interval training on neutrophilic factors of BDNF and CDNF in rats fed with high-fat foods.
Materials and Methods: In this experimental study, 42 male Wistar rats were randomly divided into 3 groups with same number: normal nutrition, high fat diet, and high fat diet + interval exercise. Interval exercises were performed in the first 3 weeks with low intensity, moderate intensity in week 4, and week of 5-8th at high intensity and 5 days in per week for 8 weeks. After the end of the eighth week, the rats were killed and the levels of the indices studied were evaluated by ELISA assay kits. One-way ANOVA and Bonferroni test were used to analyze of the data.
Results: The results showed that after a high-fat diet, there was a significant decrease in plasma levels of BDNF (P = 0.001) and CDNF (P = 0.001) compared to control group. On the other hand, after a period of interval exercise and nutrition, a significant increase was observed in BDNF levels (P= 0.001, P= 0.002) and CDNF (P= 0.001, P= 0.003) respectively, Compared to control and high fat diet groups.
Conclusion: These results may indicate the positive role of this type of exercise in preventing and neutralizing the disadvantages of high-fat diet, metabolic diseases, and as well as maintain of brain health.
Keywords: BDNF, CDNF, Full-fat diet, Interval training, Rat
Full-Text [PDF 535 kb]   (312 Downloads)    
Type of Study: Research | Subject: General
Received: 2018/12/19 | Accepted: 2019/10/8 | Published: 2020/03/21
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Asad M R, Hedayatnejad S, Barzegari A, Gholizadeh ahangari M. Investigating the Protective Effect of an Interval Training on Neutrophilic Factors of BDNF and CDNF in Rats Fed with High-fat Foods. SJKU. 2020; 25 (1) :1-11
URL: http://sjku.muk.ac.ir/article-1-4622-en.html


Volume 25, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2020) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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