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Investigating of dietary nitrate and nitrite interaction and vitamin C and urinary and serum nitrate and nitrite levels: Tehran Lipid and Glucose Study
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Zahra Bahadoran1    , Zahra Saeedirad2 , Maryam Mousavi3 , Parvin Mirmiran 4, Fereidoun Azizi5 |
1- PhD of Nutrition, Nutrition and Endocrine Research Center, Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- .MS.C student, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3- Shahid Beheshti University of Medical Sciences
4- Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran , mirmiran@endocrine.ac.ir
5- Endocrine Research Center, Research Institute for Endocrine Sciences, Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. |
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Abstract: (2135 Views) |
Background and Aim: studies show that antioxidants prevent conversion of NO3/NO2 to nitrosamines compounds. tha aim of this study was to determine the potential effect of interaction between dietary intakes of vitamin C and NO3/NO2 on urinary and serum levels of NO3/NO2.
Materials and Methods: This cross-sectional study included 251 adults aged >19 years was performed in the phase 6 of the Tehran Lipid and Glucose Study in 2015. Food intake was assessed using a semi-quantitative food frequency questionnaire. The average daily intake of nitrate and nitrite and vitamin C was estimated. Serum and urine levels of nitrate and nitrite were measured using the Grease method. In order to determine the effect of vitamin C on the interaction of nitrate and nitrite in urine and serum, linear regression test was used to modify the effects of confounders.
Results: There was a significant correlation between intake of nitrate and its urine level, above the median level of vitamin C intake (B = 0/004, P-value = 0/004). Also, this correlation remained significant after adjusting for age, sex, body mass index, calorie intake (B = 0.03, P-value = 0/001). The effect of vitamin C interactions on nitrate intake and urine level in the adjusted model for nitrate and nitrite was also found to be significant (B = 0/003 P-value = 0/001).
Conclusion: Increased intake of vitamin C significantly increases urinary excretion of nitrate and it is effective in the interaction between dietary intakes and urinary excretion of nitrate. |
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| Keywords: nitrate, nitrite, vitamin C |
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Full-Text [PDF 960 kb]
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Type of Study: Applicable |
Subject:
General
Received: 2018/12/4 | Accepted: 2020/12/20 | Published: 2022/01/3
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