[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
About the Journal
Editorial Board
Aims& Scopes
Journal News
Articles archive::
All Issues
Current Issue
For Authors::
Call for Papers
Submission Instruction
For Reviewers::
Reviewers Section
Subscription::
Registration Information
Subscription Form
Contact us::
Contact Information
Contact us
Site Facilities::
Site map
Search contents
FAQ
Top 10 contents
Inform to friends
Webmail::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Journal Citation Index

 

Citation Indices from GS

AllSince 2019
Citations90545467
h-index3825
i10-index237140

 
..
Central Library of Kurdistan University of Medical Sciences
AWT IMAGE
..
Vice-Chancellery for Research and Technology
AWT IMAGE
..
SCImago Journal & Country Rank
:: Volume 23, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2018) ::
SJKU 2018, 23(2): 81-91 Back to browse issues page
Interactive effects of reducing exercise intensity and Adiantum capillus veneris extract on remodeling and modulation of pulmonary apoptotic indices in the rats exposed to the hypoxia.
Mehdi Yadegari1 , Simin Riahy2 , Shadmehr Mirdar1 , Gholamreza Hamidian 3
1- Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Mazandaran, Mazandaran, Iran.
2- Faculty of Aerospace Medicine and subsurface, Army Medical University, Tehran, Iran.
3- Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran , hamidian@tabrizu.ac.ir
Abstract:   (5924 Views)
Background and Aim: Apoptosis is a type of programmed cell death occurring by a series of intercellular messages which is associated with tissue structure remodeling. The purpose of the present study was to investigate the interactive effects of reducing exercise intensity and Adiantum capillus veneris extract on remodeling and modulation of pulmonary apoptotic indices of the rats exposed to the hypoxia.
Material and Methods: This study included 16 male Wistar rats. After 6 weeks of high intensity interval training, the rats were kept in a hypoxic environment for 3 weeks. In hypoxic environment, half of the rats performed interval training and taper and received 500 mg/kg of Adiantum capillus veneris extract. Finally, lung tissue was extracted for immunohistochemical and stereology studies.
Results: 3 weeks of simultaneous exercise intensity and taper and Adiantum capillus veneris extract consumption in the hypoxia group led to decreased Bax/Bcl-2 ratio(p<0.05) and nematocytes-2 population (p>0.05), compared to increased alveolar nematocytes-1 population in the hypoxia group (p<0.05 ).
Conclusion: The results of this study showed that simultaneous use of exercise intensity and taper and consumption of Adiantum capillus veneris extract is effective in decreasing apoptosis and remodeling of Alveolar epithelial cells after high intensity interval training and exposure to hypoxia.
Key Words: Interval exercise training, Hypoxia, Adiantum capillus veneris, Taper.
 
Received: Sep 23, 2017     Accepted: Apr 11, 2018
Keywords: Interval exercise training, Hypoxia, Adiantum capillus veneris, Taper.
Full-Text [PDF 979 kb]   (1448 Downloads)    
Type of Study: Original Research | Subject: General
Received: 2018/05/31 | Accepted: 2018/05/31 | Published: 2018/05/31
References
1. Phaneuf S, Leeuwenburgh C. Apoptosis and exercise. Med Sci Sports Exerc 2001; 33: 393-6. [DOI:10.1097/00005768-200103000-00010]
2. Krakstad C, Chekenya M. Survival signalling and apoptosis resistance in glioblastomas: opportunities for targeted therapeutics. Mol Cancer 2010; 9: 135. [DOI:10.1186/1476-4598-9-135]
3. Youle RJ, Strasser A. The BCL-2 protein family: opposing activities that mediate cell death. Nat Rev Mol Cell Biol 2008; 9: 47-59. [DOI:10.1038/nrm2308]
4. Kroemer G, Galluzzi L, Brenner C. Mitochondrial membrane permeabilization in cell death. Physiol Rev 2007; 87: 99-163. [DOI:10.1152/physrev.00013.2006]
5. Quadrilatero J, Alway SE, Dupont-Versteegden EE. Skeletal muscle apoptotic response to physical activity: potential mechanisms for protection. Appl Physiol Nutr Metab 2011; 36: 608-17. [DOI:10.1139/h11-064]
6. Krüger K, Mooren FC. Exercise-induced leukocyte apoptosis. Exerc Immunol Rev 2014; 20: 117-34.
7. Ranjbar K, Nazem F, Nazari A, Golami MR. Effect of 10 weeks aerobic exercise training on left ventricular systolic function, Caspase-3 level and infarction size in myocardial infarction rat. Knowledge Health, J Shahroud Univ Med Sci 2015; 10: 20-9. [In Persian]
8. Ghibelli L, Fanelli C, Rotilio G, Lafavia E, Coppola S, Colussi C, et al. Rescue of cells from apoptosis by inhibition of active GSH extrusion. FASEB J 1998; 12: 479-86. [DOI:10.1096/fasebj.12.6.479]
9. Westergren‐Thorsson G, Larsen K, Nihlberg K, Andersson‐Sjöland A, Hallgren O, Marko‐Varga G, et al. Pathological airway remodelling in inflammation. Clin Respir J 2010; 4: 1-8. [DOI:10.1111/j.1752-699X.2010.00190.x]
10. Fehrenbach H. Alveolar epithelial type II cell: defender of the alveolus revisited. Respir Res 2001; 2: 33-46. [DOI:10.1186/rr36]
11. Shimoda LA, Semenza GL. HIF and the lung: role of hypoxia-inducible factors in pulmonary development and disease. Am J Respir Crit Care Med 2011; 183: 152-6. [DOI:10.1164/rccm.201009-1393PP]
12. Jain M, Sznajder JI. Effects of hypoxia on the alveolar epithelium. Proc Am Thorac Soc 2005; 2: 202-5. [DOI:10.1513/pats.200501-006AC]
13. Mujika I. Intense training: the key to optimal performance before and during the taper. Scand J Med Sci Sports 2010; 20: 24-31. [DOI:10.1111/j.1600-0838.2010.01189.x]
14. Yuan Q, Zhang X, Liu Z, Song S, Xue P, Wang J, et al. Ethanol extract of Adiantum capillus-veneris L. suppresses the production of inflammatory mediators by inhibiting NF-κB activation. J Ethnopharmacol 2013; 147: 603-11. [DOI:10.1016/j.jep.2013.03.046]
15. Yadegari M, Mirdar S, Hamidian Gh. The effect of high-intensity interval training on lung parenchymal and non-parenchymal structural changes. Daneshvar Med 2016; 23: 51-60. [In Persian]
16. Mirdar S, Arabzadeh E, Hamidian Gh. Effects of two and three weeks of tapering on lower respiratory tract in the maturing rat. Koomesh 2015; 16: 366-75. [In Persian]
17. Nilforoushzadeh MA, Javanmard SH, Ghanadian M, Asghari G, Jaffary F, Yakhdani AF, et al. The effects of Adiantum capillus-veneris on wound healing: An experimental in vitro evaluation. Int J Prev Med 2014; 5: 1261-8.
18. Schneider JP, Ochs M. Stereology of the lung. Methods Cell Biol 2013; 113: 257-94. [DOI:10.1016/B978-0-12-407239-8.00012-4]
19. Ochs M, Mühlfeld C. Quantitative microscopy of the lung: a problem-based approach. Part 1: basic principles of lung stereology. Am J Physiol Lung Cell Mol Physiol 2013; 305: L15-22. [DOI:10.1152/ajplung.00429.2012]
20. Hofman F. Immunohistochemistry. Curr Protoc Immunol 2002; 21: 21-4. [DOI:10.1002/0471142735.im2104s49]
21. Di Cataldo S, Ficarra E, Acquaviva A, Macii E. Automated segmentation of tissue images for computerized IHC analysis. Comput Methods Programs Biomed 2010; 100: 1-15. [DOI:10.1016/j.cmpb.2010.02.002]
22. Wendakoon C, Calderon P, Gagnon D. Evaluation of selected medicinal plants extracted in different ethanol concentrations for antibacterial activity against human pathogens. J Med Act Plants 2012; 1: 60-8.
23. Yadegari M, Riahi S, Mirdar S, Hamidian Gh, Yousefpour M. Riyahi F. Immunohistochemical detection of apoptotic factors Bax and Bcl-2 in the lung alveoli, followed by six weeks of high intensity exercise training. Daneshvar Med 2016; 24: 31-40. [In Persian]
24. Lee SD, Kuo WW, Lin JA, Chu YF, Wang CK, Yeh YL, et al. Effects of long-term intermittent hypoxia on mitochondrial and Fas death receptor dependent apoptotic pathways in rat hearts. Int J Cardiol 2007; 116: 348-56. [DOI:10.1016/j.ijcard.2006.03.064]
25. Yadegari M, Mirdar S, Hamidian Gh, editors. The impact of three weeks taper in hypoxic environment on apoptotic index of Bax / Bcl2 and pulmonary alveolar epithelial cell population. Proceedings of 10th International Congress on Sport Science. 2017 April. 26-27, Tehran, Iran.
26. Yuan Q, Zhang X, Liu Z, Song S, Xue P, Wang J, et al. Ethanol extract of Adiantum capillus-veneris L. suppresses the production of inflammatory mediators by inhibiting NF-κB activation. J Ethnopharmacol 2013; 147: 603-11. [DOI:10.1016/j.jep.2013.03.046]
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA

XML   Persian Abstract   Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:
Yadegari M, Riahy S, Mirdar S, Hamidian G. Interactive effects of reducing exercise intensity and Adiantum capillus veneris extract on remodeling and modulation of pulmonary apoptotic indices in the rats exposed to the hypoxia.. SJKU 2018; 23 (2) :81-91
URL: http://sjku.muk.ac.ir/article-1-4109-en.html
Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 23, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2018) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
Persian site map - English site map - Created in 0.1 seconds with 45 queries by YEKTAWEB 4645