[Home ] [Archive]   [ فارسی ]  
:: Volume 23, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2018) ::
SJKU 2018, 23(1): 26-37 Back to browse issues page
Protective effects of aqueous extract of internal septum of walnut fruit on diabetic hepatopathy in streptozotocin-induced diabetic mice
Akram Zangeneh 1, Mahdi Zangeneh 1, Nader Ghoodarzi Dr 2, Fariba Najafi Dr3, Lida Hagh Nazari Dr4
1- DVM Student, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.
2- Assistant Professor Department of Basic and Pathobiological Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran , n.goodarzi@razi.ac.ir
3- Assistant Professor Department of Dermatology, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
4- Assistant Professor Department of Biochemistry, Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Abstract:  
Backgrounds and Aim: Treatment of diabetes by ethnomedicinal plants which have fewer side effects than chemical drugs has been on the rise. In this study we assessed hepatoprotective and antidiabetic effects of aqueous extract of internal septum of walnut fruit (ISWF) on diabetic mice.
Material and Methods: In this experimental study 35 mature male mice were made diabetic by administration of 60 mg/kg of streptozotocin intraperitoneally. The mice were randomly divided into 5 groups. The negative (non diabetic) and positive (diabetic) control groups received normal saline and the 1st, 2nd and 3rd treatment groups received 0.5 mg/kg of glibenclamide, 200 and 400 μl/kg of aqueous extract of ISWF through gavage respectively for 15 days. On the last day, serum levels of blood glucose, ALT (alanine aminotransferase), AST (aspartate aminotransferase) and ALP (alkaline-phosphatase) were measured. After tissue processing, we measured total volume of the liver, hepatocytes, sinusoids, portal vein, central vein, hepatic arteries and bile ducts in the sections of the tissues.
Results: Use of aqueous extract of ISWF in the treatment groups led to significant decrease in blood glucose levels, AST and ALP enzymes and also total volume of liver, sinusoids and central vein (p<0.05) compared to those in the non-treated diabetic group.
Conclusion: According to the results, aqueous extract of ISWF, can regulate the blood glucose level and inhibit hepatic damage in streptozotocin-induced diabetic mice.
Key Words: Internal septum of walnut fruit, Streptozotocin, Diabetes, Liver, Mice.
 
Received: May 30, 2017     Accepted: Jan 8, 2018
Keywords: Internal septum of walnut fruit, Streptozotocin, Diabetes, Liver, Mice.
Full-Text [PDF 678 kb]      
Type of Study: Research | Subject: General
Received: 2018/03/17 | Accepted: 2018/03/17 | Published: 2018/03/17
Send email to the article author

Add your comments about this article
Your username or Email:

Write the security code in the box >


XML   Persian Abstract   Print



Volume 23, Issue 1 (Scientific Journal of Kurdistan University of Medical Sciences 2018) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
Persian site map - English site map - Created in 0.05 seconds with 30 queries by YEKTAWEB 3638