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:: Volume 23, Issue 5 (Scientific Journal of Kurdistan University of Medical Sciences 2018) ::
SJKU 2018, 23(5): 78-87 Back to browse issues page
Effect of sodium valproate on adjusting increased hippocampal levels of NF-KB, S100B and GFAP following alloxan induced diabetes
Behnam Amirpour-najafabadi 1, Mahsa Gholami 2, Parvin Zarie , Sirvan Hossieni 1, Mehdi Sadegh 1
1- Student Research Committee, Arak University of Medical Sciences, Arak, Iran
2- Department of Biochemistry and Genetic, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran
Abstract:   (282 Views)
Background and Aim: Peripheral and central nervous system neuropathy occur in chronic diabetes with uncontrolled hyperglycemia. Beneficial effects of sodium valproate have been demonstrated in neurodegenerative diseases. Sodium valproate has neuroprotective and regenerative effects via modifications in gene expression. In this study, we investigated effects of sodium valproate on the modifications in the hippocampal levels of NF-KB, AP-1, S100B and GFAP as a consequence of alloxan induced diabetes.
Material and Methods: This experimental study included 24 adult male C57B15/J mice. Diabetes was induced by injection of alloxan (150 mg/kg; i.p.). Sodium valproate was administrated (100 mg/kg; i.p) every 72 hours for two months. Fasting blood sugar levels were measured at the beginning and at the end of the experiment. Then animals were killed, their hippocampuses were extracted and prepared for measurement of biochemical factors by ELISA kits.
Results: Increased blood glucose levels due to alloxan induced diabetes were significantly reduced following sodium valproate administration (P<0.05). Also, chronic sodium valproate administration in diabetic animals significantly reduced elevated levels of hippocampal NF-KB, S100B and GFAP (P<0.05).
Conclusion: It seems that sodium valproate can adjust diabetes induced modifications in the biochemical factors of the hippocampus which are indicators of cell damage, and maybe effective in prevention of diabetic neuropathy.
Keywords: Learning, Morris Water Maze, Neuronal count, Neuropathy
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Type of Study: Research | Subject: General
Received: 2017/12/8 | Accepted: 2018/11/20 | Published: 2018/11/20
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Amirpour-najafabadi B, Gholami M, Zarie P, Hossieni S, Sadegh M. Effect of sodium valproate on adjusting increased hippocampal levels of NF-KB, S100B and GFAP following alloxan induced diabetes. SJKU. 2018; 23 (5) :78-87
URL: http://sjku.muk.ac.ir/article-1-3609-en.html


Volume 23, Issue 5 (Scientific Journal of Kurdistan University of Medical Sciences 2018) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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