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:: Volume 22, Issue 5 (Scientific Journal of Kurdistan University of Medical Sciences 2017) ::
SJKU 2017, 22(5): 13-21 Back to browse issues page
Effect of folate supplementation during 10 weeks of HIIT on serum levels of ghrelin and leptin in male Wistar rats
Ali Gorzi Dr1, Leila Taherkhani Dr *2, Ahmad Rahmani Dr3
1- Associate Professor Department of physical education and sports sciences, University of Zanjan, Zanjan ,Iran.
2- Master in Exercise physiology, University of Zanjan, Zanjan, Iran , taherkhani.leila9@gmail.com
3- Assistant Professor Department of physical education and sports sciences, University of Zanjan, Zanjan, Iran.
Abstract:  
Background and Aim: Exercise training is one of the contributing factors in appetite changes. The purpose of this study was to investigate the effect of folate supplementation on serum levels of ghrelin and leptin during 10 weeks of high intensity interval training in male Wistar rats.
Materials and methods: After a period of familiarization for one week, 27 male Wistar rats (weight= 203/94 ± 27/34gr, Age: 9 weeks), were randomly divided into four groups: control (n=6), folate supplementation (n=6), high intensity interval training (n =7) and HIIT+folate supplementation (n =8). HIIT training protocol started with speed of 30 m/min for 1 min with 10 reps and 2 min active rest in the first week and reached to 75-80 m/min for 1 min with 7 reps and 3 min active rest in the last week. Folate supplementation carried out by dissolving folate tablets in drinking water. 48 hrs after the last training session, animals were anesthetized, serum samples were collected and ghrelin and leptin levels of serum were measured by using ELISA kit.
Results: The results of this study showed that serum ghrelin level increased significantly (P=0/01) in folate+HIIT group compared to those in HIIT groups. Also, there was a significant decrease (P=0/35) in serum leptin levels in the folate, HIIT and folate+HIIT groups compared to that in the control group but, we found no such significant (P=0/955) differences between folate+HIIT and HIIT groups.
Conclusions: According to our results, folate supplementation during high intensity interval training resulted in increased serum ghrelin level. Therefore folate supplementatian can prevent loss of appetite in the athletes who perform high intensity interval training.
Keywords: High intensity interval training, Folate supplementation, Ghrelin, leptin, Appetite.
 
Received: Jan 17, 2016     Accepted: Jun 17, 2017
Keywords: High intensity interval training, Folate supplementation, Ghrelin, leptin, Appetite.
Full-Text [PDF 210 kb]      
Type of Study: Research | Subject: General
Received: 2017/11/15 | Accepted: 2017/11/15 | Published: 2017/11/15
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Volume 22, Issue 5 (Scientific Journal of Kurdistan University of Medical Sciences 2017) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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