[Home ] [Archive]   [ فارسی ]  
:: Volume 21, Number 2 (Scientific Journal of Kurdistan University of Medical Sciences 2016) ::
SJKU 2016, 21(2): 75-84 Back to browse issues page
Interaction between melatonin and exercise in the spatial memory and learning performance in rats
Saman Gholamrezaei, Majid Taati 1
1- , Taatimajid@yahoo.com
Abstract:  

Background and Aim: Physical exercise and melatonin have considerable effects on cognitive functions such as spatial memory and learning performance. The aim of this study was to clarify the possible interaction between the exercise and melatonin and its effects on spatial memory and learning performance in rats.

Material and Method: In this experimental study groups of rats underwent 2 interventions. In experiment 1, Wistar rats were divided into groups (7 in each group), as follows: sedentary-vehicle, treadmill exercise-vehicle, and sedentary-melatonin and treadmill exercise-melatonin. In experiment 2, groups were designed as; sedentary-saline, treadmill exercise-saline, sedentary-lozindole and treadmill exercise-lozindole (M1 and M2 melatonin receptor blocker). The animals received drugs and vehicles intraperitoneally, 30 minutes before treadmill exercise, every day for fifteen consecutive days. Then their learning and spatial memory performance was evaluated using Moris water maze task. Data analysis was performed by two way analysis of variance.

Results: Melatonin significantly attenuated learning and memory performance in both exercised and non-exercised rats. Blocking the melatonin receptors by lozindole improved spatial memory in the rest condition, but had no significant effect on the learning and spatial memory after exercise.

Conclusion: The findings of this study indicated that exercise had beneficial effects on learning and spatial memory independent of melatonin and its receptors.

Keywords: Melatonin, Exercise, Spatial memory, Learning.

Received: Dec 01, 2015      Accepted: Jan 11, 2016

Keywords: Melatonin, Exercise, Spatial memory, Learning.
Full-Text [PDF 447 kb]      
Type of Study: Research | Subject: General
Received: 2016/06/11 | Accepted: 2016/06/11 | Published: 2016/06/11
Send email to the article author

Add your comments about this article
Your username or email:

Write the security code in the box >



XML   Persian Abstract   Print


Volume 21, Number 2 (Scientific Journal of Kurdistan University of Medical Sciences 2016) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
Persian site map - English site map - Created in 0.046 seconds with 775 queries by yektaweb 3461