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:: Volume 20, Number 6 (Scientifis Journal of Kurdistan University of Medical Sciences 2016) ::
SJKU 2016, 20(6): 26-33 Back to browse issues page
Comparison of the effect of single and multiple-dose methotrexate therapy on tubal patency in women with ectopic pregnancy
Dr Taravat Fakheri1, Dr Nazanin Farshchian1, Dr Mansour Rezaie1, Dr Seyedeh Mozhgan Seyedzadeh 2
1- Associate Professor
2- , Sm.seyedzadeh@kums.ac.ir
Abstract:  

Background and Aim: Ectopic pregnancy is one of the leading causes of death among the women of reproductive age. Injection of single or multiple doses of methotrexate can be used as a therapeutic approach. The aim of this study was to compare the effect of single and multiple-doses of methotrexate therapy on the tubal patency in women with ectopic pregnancy.

Material and Methods: This was an interventional study and included 80 patients with ectopic pregnancy who had been treated with a single dose or multiple doses of methotrexate. After 3 months of hospitalization and treatment, hysterosalpingography was conducted to assess tubal patency. Data were analyzed using SPSS version 21.

Results: The frequencies of ipsilateral tubal obstruction were 12 (30%) and 3 (7.5%) in the patients who had received multiple-doses of methotrexate and single-dose methotrexate respectively. Also, 33 (82.5%) patients in the single-dose methotrexate group and 18 (45%) patients in the multiple-dose methotrexate group did not have bilateral obstruction. There was a significant difference in the frequencies of tubal obstruction between the two groups treated with single and multiple doses of methotrexate (P<0.05).

Conclusion: The incidence of tubal obstruction in women with ectopic pregnancy was significantly lower in single-dose methotrexate group compared to multiple dose methotrexate groups.

Keywords: Ectopic pregnancy, Tubal obstruction, Single-dose methotrexate, Multiple dose methotrexates.

 

Received: Apr 28, 2015      Accepted: Nov 23, 2015

Keywords: Ectopic pregnancy, Tubal obstruction, Single-dose methotrexate, Multiple dose methotrexates.
Full-Text [PDF 151 kb]      
Type of Study: Research | Subject: General
Received: 2016/02/8 | Accepted: 2016/02/8 | Published: 2016/02/8
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Volume 20, Number 6 (Scientifis Journal of Kurdistan University of Medical Sciences 2016) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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