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:: Volume 20, Number 4 (Scientific Journal of Kurdistan University of Medical Sciences 2015) ::
SJKU 2015, 20(4): 83-90 Back to browse issues page
Effects of drug substance crystal (methamphetamine) on histopathology and biochemical parameters of kidney in adult male mice
Dr Shabnam Mohammadi1, Zahra Pakrouh 2, Mahin Teimouri, Saedeh Haji Pour, Dr Mehdi Karimi1, Dr Maryam Mohammadi1, Dr Ali Mohammad Pour3, Mohammad Hossein Tani Pour, Dr Isaac Hashemi1, Dr Mohammad Sookhtanlu1, Dr Kamyar Tavakkoli1, Fatemeh Mohammadzadeh4
1- Assistant Professor
2- , Dr.paper57@gmail.com
3- Associate Professor
4- Instructor
Abstract:  

Background and Aim: Methamphetamine causes damage in different body organs. The aim of this study was to investigate the effects of methamphetamine on morphometric changes and biochemical parameters in kidney of adult mice. 

Material and Methods: In this experimental study, 56 mice were randomly divided into 7 groups: control and 6 experimental groups. Experimental groups 1, 2 and 3 received methamphetamine 5, 10 and 20 mg/kg respectively for 10 days.  Experimental groups 4, 5 and 6 received methamphetamine (5, 10 and 20 mg/kg) respectively for 40 days. After 10 and 40 days, kidneys of the mice of the experimental groups were removed and after tissue processing and imaging, volume of kidney and glomerulus were measured by using cavalieri's principle. In addition blood urea and creatinine levels were measured. Using SPSS software, data were analyzed by means of ANOVA.    

Results: Histopatological study showed that methamphetamine increased renal damage in a dose dependent manner. High doses of methamphetamine caused a moderate lobulation, glomerulosclerosis and kidney congestion. There was also a significant difference between the experimental (groups 3 to 6) and control groups in regard to the volumes of kidney and glomerulus (P=0.000).     

Significant differences were found in the level of urea in group 6 and creatinine levels in all experimental groups compared to those of control group (P=0.000).    

Conclusion: Use of 10 mg/kg of methamphetamine for 40 days led to destructive effects on kidney tissue. Also, it increased serum levels of urea and creatinine.

Keywords: Methamphetamine, Kidney, Mice.

 

Received: Dec 31, 2014      Accepted: Jun 6, 2015

Keywords: Methamphetamine, Kidney, Mice
Full-Text [PDF 560 kb]      
Type of Study: Research | Subject: General
Received: 2015/10/19 | Accepted: 2015/10/19 | Published: 2015/10/19
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Volume 20, Number 4 (Scientific Journal of Kurdistan University of Medical Sciences 2015) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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