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:: Volume 20, Number 4 (Scientific Journal of Kurdistan University of Medical Sciences 2015) ::
SJKU 2015, 20(4): 73-82 Back to browse issues page
Effect of hydroalcoholic extract of Rosa damascena on post-laparotomy intra-abdominal adhesions in rat
Sare Ezzati, Seyed Yazdan Asadi, Pooya Parsaei, Dr Mahmood Rafieian-kopaei1, Dr Mehrdad Karimi 2
1- Professor
2- Assistant Professor , dr.karimi.mehrdad@gmail.com
Abstract:  

Background and Aim: Peritoneal adhesions can be defined as abnormal fibrous bands between peritoneal or pelvic cavity. Flavonoid agents with antioxidant properties are present in Rosa damascene and seem to be useful for prevention of intra-abdominal adhesion formation. Therefore, the present study aimed to examine the effect of R. damascena hydroalcoholic extract on prevention of adhesions.

Material and Methods: In this experimental study, 30 rats were divided randomly into 3 groups group A received 1% extract, group B 5% extract and group C distilled water. During laparotomy, three longitudinal and transvers incisions each of 2 cm length were made in the serous surface by scalpel in the right and left sides of peritoneum, and a 2x2 cm patch was completely cut off. Group A and B received 1% and 5% hydroalcoholic extract of R. damascena (3 ml, intra-abdominal cavity) respectively and group C received distilled water during the surgery. Two weeks later in the second laparotomy, the adhesions were graded by means of Canbaz scale. Using SPSS v.16 software, data were analyzed by Mann-Whitney test.

Results: There were significant differences between the scores of groups A and C (P = 0.007). The mean adhesion scores were 1.4 ± 1.265 and 3 ± 0.816 in groups A and C respectively.

Conclusion: Results of this study demonstrated that use of R. damascena 1% extracts may result in effective prevention of postoperative intra-abdominal adhesions. After more studies in the future, R. damascena or its derivatives may prove to be useful for prevention of adhesions.  

Keywords: Intra-abdominal adhesion, Rosa damascena, Laparotomy, Rat.

 

Received: Feb 28, 2015      Accepted: Jun 28, 2015

Keywords: Intra-abdominal adhesion, Rosa damascena, Laparotomy, Rat
Full-Text [PDF 535 kb]      
Type of Study: Research | Subject: General
Received: 2015/10/19 | Accepted: 2015/10/19 | Published: 2015/10/19
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Volume 20, Number 4 (Scientific Journal of Kurdistan University of Medical Sciences 2015) Back to browse issues page
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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