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Investigatation of diagnostic value of random urine protein/creatinine ratio in pre-eclampsia
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Farnaz Zandvakili   , Sara Matini , Ezatollah Rahimi 1, Shoaleh Shahgheibi , Ebrahim Ghaderi , Naser Reshadmanesh |
| 1- , e_rahimi258@hotmail.com |
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Abstract: (7797 Views) |
| Background and Aim: Standard diagnostic procedure for significant proteinuria is based on 24-hour urine collection. However, this method is time consuming and may lead to incomplete urine collection. Instead, random urine protein/creatinine ratio could be used as an alternative method for evaluation of proteinuria. This study investigates the diagnostic value of random urine protein/creatinine ratio for the diagnosis of pre-eclampsia.
Material and Methods: In this cross-sectional study a group of 96 patients with pre-eclampsia and a group of healthy pregnant women were recruited. All cases were checked for urine protein by assessing urine analysis, 24-hour urine, and random urine protein/creatinine ratio. Data were analyzed using SPSS and ROC curve. Then a cutoff point of random urine protein/ creatinine ratio was determined.
Results: Area under the curve for random Pr/Cr was calculated as 0.785 (CI %95: 0.721-0.849) (p<0.001). The best diagnostic cutoff point for protein/creatinine ratio was determined as 0.325. In this point sensitivity and specificity were 81.3% and 66.7% respectively. As a result, a positive correlation between random urine protein/creatinine ratio and systolic blood pressure (r = 0.284, p = 0.005) was observed.
Conclusion: Based on these results, random urine protein/creatinine ratio in a cutoff point of 0.325 could be suggested for preeclampsia.
Keywords: Preeclampsia, Proteinuria, Diagnosis.
Received: Oct 19, 2014 Accepted: Feb 24, 2015 |
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| Keywords: Preeclampsia, Proteinuria, Diagnosis. |
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Full-Text [PDF 336 kb]
(15415 Downloads)
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Type of Study: Original Research |
Subject:
General
Received: 2015/07/12 | Accepted: 2015/07/12 | Published: 2015/07/12
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