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Metheds for Studing Apoptosis in Bone Cells
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Maryam Sohrabi1   , Sayed Mohsen Shataheri |
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Abstract: (28770 Views) |
| ABSTRACT
Apoptosis is a common form of cell death. The biological significance of apoptosis in pathogenesis of cancer , fetal development and normal immune response has been recognized widely since two last decades. Apoptosis, like as proliferation, is a major factor in function of most cells including bone cells.Bone is a calcified tissue with a few number of cells. So, it is defficult to study apoptosis of bone cells.There is several methods for detection of apoptosis that include: gel electrophoresis, electron microscopy, light microscopy, nick-end labelling of DNA , fluoresence techniques, and detection of phosphatidyl serine.These techniques also demonstrate the affected components in the cell during apoptosis.New methods lead to a better understanding of the mechanism of action of drugs currently used to treat patients with bone diseases, and possibly production of new drugs designed to maintain or increase bone mass by either promoting or preventing apoptosis of bone cells. |
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| Keywords: Apoptosis, Bone cells, Cell death |
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Full-Text [RTF 119 kb]
(4579 Downloads)
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Type of Study: Original Research |
Subject:
General
Received: 2009/03/8 | Published: 2000/09/15
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