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Comparison of sedative effects of propofol-ketamine with propofol during retrobulbar nerve block in cataract surgery
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Mitra Golmohammadi   1, Mohammad Shirvani |
| 1- , mitragmd@yahoo.com |
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Abstract: (10322 Views) |
| Background and Aim: Retrobulbar block is a relatively unpleasant and painful procedure. For well being and safety of the patients during retrobulbar block, sedation is required. This study was designed to compare the sum of sedative effects of ketamine and propofol with that of propofol alone in patients receiving retrobulbar block for cataract surgery.
Material and Methods: Sixty patients were assigned into two groups randomly and received retrobulbar nerve block for cataract surgery. Under identical conditions, in the propofol group sedation was induced with 0.3mg/kg propofol while sedation in ketamine plus propofol group was induced with 0.3mg/kg propofol plus 0.15mg/kg ketamine. In all patients, vital signs, the status of sedation and hypnoses, intraocular pressure, amnesia, onset and duration of sedation were measured and recorded. Side effects of the drugs were evaluated in the first 24 h after operation. Data were analyzed by means of T-test and x2.
Results: Duration of sedation was longer in ketamine plus propofol group (5.8±2.8 min) than that of propofol group (4.1±2.4 min) (p<0/05(. Intraocular pressure in ketamine plus propofol group was less than that of propofol group (p>0/05). On the other hand ketamine plus propofol group patients showed a decline in the need for excess sedation, awareness, and psychological reactions. Seven patients in propofol group developed vertigo and six patients in ketamine plus propofol group developed agitation as the side effects of these drugs.
Conclusion: Addition of low dose ketamine to propofol will increase duration of sedation and decrease IOP, without increasing unwanted side effects, in comparison with propofol alone for performing retrobulbarblock,.
Conflict of Interest: Nill
Received: Dec 14, 2008 Accepted: April 15, 2009 |
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| Keywords: Retrobulbar nerve block, Sedation, Propofol, Ketamine, Cataract Surgery. |
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Full-Text [PDF 149 kb]
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Type of Study: Original Research |
Subject:
General
Received: 2009/06/15 | Published: 2009/06/15
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