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Prevalence of HBeAg and liver transaminase survey in HBsAg positive blood donors in Sanandaj
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Shahin Kanani1   , Vahid Yousefinejad |
| 1- , drshsananadaj@yahoo.com |
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Abstract: (20382 Views) |
| Background and Aim: Hepatitis-B virus (HBV) is one of the most common chronic pathogens in the world. More than 2 billion people in the world have been exposed to this virus and 350 million of them (5% of world population) are chronic carriers of HBV. One of the most common ways of transmission of this virus is transfusion of blood and its products. For this reason blood transfusion organization controls all blood products for HBsAg. In HBV chronic carriers viral replication should be detected by use of suitable antigenic markers such as HBeAg. Therefore HBeAg positive patients with elevated liver enzymes can be recognized and treated for chronic hepatitis. The aim of this study was to detect prevalence rates of HBeAg positivity, elevated liver transaminases in HBsAg positive individuals, and recognition of chronic hepatitis patients in Sanandaj from 1383 to 1384.
Materials and Methods: This study was a descriptive- analytic cross sectional study. The sampling method was census. 139 HBsAg positive people between 18-65 years of age were entered into the study.
Results: According to the results of this study 20 subjects (14/4%) were HBeAg positive with no significant correlation between the male and female ratio. Measurement of liver transaminases at the same time showed that 7 HBeAg positive patients (35%) had higher than normal serum AST levels (≥47 IU/L) (p=0.001) and 8 other (40%) had higher serum ALT levels (≥47 IU/L) (p=0.000). In general in 7(35%) HBeAg positive patients both AST and ALT were elevated but only 7 HBeAg negative persons (5.9%) had elevation of both enzymes.
Conclusion: This study revealed HBeAg positivity may be considered a risk factor for elevated aminotransferases levels and chronic hepatitis was prevalent in a significant number of HBsAg positive blood donors, but severe liver disease was absent. |
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| Keywords: Prevalence, HBsAg, HBeAg, Liver transaminase, Blood donors, Sanandaj |
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Full-Text [PDF 152 kb]
(1926 Downloads)
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Type of Study: Original Research |
Subject:
General
Received: 2009/05/12 | Published: 2006/09/15
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