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The effects of cigarette or waterpipe smoke and immobilization on serum levels of TSH, T3 or T4 in male rats
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Rahim Ahmadi1   , Gholamreza Abedi 2, Vahid Asgari3 |
1- Islamic Azad University, Hamedan Branch
2- Islamic Azad University, Hamedan Branch , Abedi01@yahoo.com
3- Tehran University of Medical Sciences |
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Abstract: (15005 Views) |
| ABSTRACT
Background and Aim: The results of different studies have shown smoking can influence functions of thyroid gland. The aim of this study was to determine the effects of cigarette or water pipe smoking and immobilization on serum levels of TSH, T3 and T4 in male rats.
Material and Methods: In this laboratory experimental study, male Wistar rats were randomly divided into the following groups: control,rats exposed to cigarette smoke ,rats exposed to waterpipe smoke, chronically immobilized rats, and chronically immobilized rats exposed to cigarette or waterpipe smoke. Each group consisted of 5 rats. After 6 weeks blood samples were collected by cardiac puncture method. After obtaining serum, levels of TSH, T3 or T4 were measured by radioimmunoassay method. Data were statistically analyzed and compared among the groups by means of one way ANOVA.
Results: Serum TSH levels were not significantly changed in experimental groups comaperd to control animals. Serum T3 and T4 levels were significantly increased in rats exposed to waterpipe smoke as compared to control animals (P<0.01). There were also a significant increase in T3 and T4 levels in the rats exposed to cigarette smoke compared to control rats (P<0.001 and P<0.01, respectively). Serum levels of T3 or T4 showed no significant alterations in immobilized rats, but significantly increased in immobilized rats exposed to cigarette or waterpipe smoke in comparison to control or immobilized animals (P<0.01).
Conclusion: Our findings showed that exposure to cigarette and water pipe smoke can increase serum levels of T3 or T4 and may be a predisposing factor in the development of hyperthyroidism.
Key Words: Cigarette, Water pipe, Immobilization, TSH, T3, T4, Rat.
Received: Jun 6, 2012 Accepted: May 12, 2013
Conflict of interest: None declared |
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| Keywords: Cigarette, Water pipe, Immobilization, TSH, T3, T4, Rat. |
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Full-Text [PDF 231 kb]
(1596 Downloads)
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Type of Study: Original Research |
Subject:
General
Received: 2013/10/4 | Published: 2013/10/15
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