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Quntitative Analysis of Mast Cells in Seminal Vesicles of Adult Rat During Acute Phase of Spinal Cord Injury
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Mohammad Jafar Rezaie   1, Shohreh Rezaie |
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Abstract: (16625 Views) |
| ABSTRACT
INTRODUCTION: This study was aimed to evaluate changes in number and distribution of mast cells in seminal vesicles of rat during acute phase of spinal cord injury (SCI).
MATERIALS & METHODS: This research was a randomized clinical trial. Forty three 2- month-old rats of sprague race were selected and divided to the control and case groups. In the case group spinal cord disscection at the level of T9 was performed following local anesthesia and laminectomy. In the cotrol group, only laminectomy of the T9 was performed but the cord remained intact. In both groups biopsy from seminal vesicls was perfomed in the first, second and third weeks after surgery. Serial sections of speciments were stained with Toluidine-blue. Then mast cells in the connective and mucusal tissues were counted. The results were analysed by mann whitney U test.
RESULTS: The number of mast cells in the case group was increased as compared with control group both in the first (11.630.59 versus 8.0140.22) and second 8.140.85 versus 70.77.84) weeks (P<0.001).
CONCLUSIONS: Increased number of mast cells, particularly mucusal mast cells, is due to epithelial damage during actue phase of SCI. This may be a cause of increase in antibody titer in the semen that may have a roll in infertility of the patients with SCI. |
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| Keywords: Spinal cord injury, Seminal vesicle, Mast cell, Infertility |
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Full-Text [RTF 79 kb]
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Type of Study: Original Research |
Received: 2009/03/7 | Published: 2000/09/15
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