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Journal Citation Index

 

Citation Indices from GS

AllSince 2020
Citations102885691
h-index3925
i10-index271142

 

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Central Library of Kurdistan University of Medical Sciences
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Vice-Chancellery for Research and Technology
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Showing 5 results for Homocysteine

Saeed Emamdoost, Dr Mohammad Faramarzi, Laleh Bagheri, Dr Khadijeh Otadi, Ehsan Razaghi Naeeni, Dr Tahereh Yazdani, Ali Dirandeh,
Volume 20, Issue 1 (4-2015)
Abstract

Background and Aim: Homocysteine is a new cardiovascular risk factor that its increased concentration can lead to increased rate of cardiovascular diseases. The purpose of the present study was to examine the effect of an 8-week concurrent training (resistance and aerobic) on serum level of homocysteine and lipid profile in overweight men. Material and Methods: Thirty overweight males (age=22-42 years old and BMI≥29) were randomly divided into experimental (n=15) and control groups (n=15). The experimental group performed 3 sessions of aerobic and resistance training every week, for 8weeks. Each session included 10-12 stations of strength training with intensity of 80-70% of 1RM and in the last session, subjects performed aerobic running exercise for 12-20 minutes with 80-70% of MHR. We used independent t-test to make comparison between the groups and paired t-test to compare pretest and post test results. Results: The results showed that homocysteine serum concentrations were not significantly changed after 8-week of concurrent training (P≥0.05). However, cholesterol(P=0.01), body weight(P=0.001) and body mass index (BMI)(P=0.01) significantly decreased after the training. Conclusion: In general, it seems that concurrent training can lead to positive effect on lipid profile of obese men. On the other hand, we did not find any significant change in the plasma homocysteine level which can be due to inadequate duration and intensity of the training. Key Words: Concurrent training, Homocysteine, Lipid profile Received: Sep 6, 2014 Accepted: Dec 22, 2014
Saber Saedmocheshi , Dr Lotfollah Saedmocheshi , Mohammad Reza Almori, Ghafoor Ghafari,
Volume 20, Issue 3 (7-2015)
Abstract

Background and Aim: Cardiovascular diseases, especially atherosclerosis are the main cause of death worldwide which its prevalence is increasing in Iran as well. The present study examined the effect of grape seed supplement and aerobic activity on cardiovascular risk in elderly women. Materials and Methods: In a double-blind study, 24 obese women (BMI≥30), 55 to 65 years old were randomly divided into two groups of exercise with supplement (12 individuals) and exercise (12 individuals). Aerobic training program was performed 1 hour per session, 3 sessions per week during 8 weeks (with 45 to 55 percent of maximum heart rate). A daily dose of 200 mg grape seed extract was used for 8 weeks in supplement group. Blood samples were collected before and 48 hours after the last session of the study (12h fasting). Dependent t-test and independent t-test were used to compare data before and after the study and for comparison between two groups respectively. Results: Data showed a significant difference in amount of homocysteine, hs-CRP, cholesterol, triglyceride and LDL-C between pretest and posttest of supplement group, while there was no difference in any variable in the control group. Conclusion: According to the present study, 8 weeks aerobic exercise and consumption of grape seed extract can prevent atherosclerosis and improve public health. Also it may control and reduce atherosclerosis in obese individuals. Keywords: Aerobic exercise, Homocysteine, Fibrinogen, Atherosclerosis, Grape Seed Extract. Received: Dec 7, 2014 Accepted: Apr 4, 2015
Reza Gharari Arefi , Dr Marzieh Saghebjoo, Dr Mahdi Hedayati, Dr Rozita Fathi,
Volume 21, Issue 2 (6-2016)
Abstract

Background and Aim: Brain-derived neurotrophic factor (BDNF) is widely expressed in the brain, but it is reduced significantly in the brain of the patients with Alzheimer's disease. The aim of the present study was to assess the impact of low intensity aerobic training and Omega-3 consumption on hippocampal BDNF levels in male rat with homocysteine induced Alzheimer’s disease.

Material and Methods: 60 Wistar male rats (12 weeks old and mean weight of 222.31±11.91 g) were divided into six groups, including: Alzheimer’s rat with training, Alzheimer’s rat with training+Omega-3 intake, Alzheimer’s rat + supplement of Omega 3, healthy control rat, Alzheimer’s control rat and sham. Alzheimer's disease was induced by injection of homocysteine (0.6M) into the rat brain ventricle. Training with a speed of 20 meters per minute (intensity of 50-55% VO2max) was done for 5 days a week on the treadmill. Each session lasted 60 minutes. The supplement groups received, 800 mg per kg of Omega-3/day for 8 weeks. We used one-way analysis of variance for data analysis. P <0.05 considered significant

Results: The results of this study showed that, 8 weeks of aerobic training and intake of omega-3, had no significant effect on the BDNF level in the hippocampus of Alzheimer induced rats (P=0.06).

Conclusion: According to the results of this study, it seems that aerobic training and use of omega-3 in the short-term cannot increase BDNF levels in the hippocampus of Alzheimer induced rats. But it is possible that aerobic training with higher intensity along with use of higher amounts of Omega-3 for longer periods may affect the BDNF level in the hippocampus.

Keyword: Aerobic training, Alzheimer's disease, Brain-derived neurotrophic factor, Hippocampus, Homocysteine.

Received: Oct 03, 2015      Accepted: Feb 14, 2016


Zaher Etemad, Dr Hojatollah Nikbakht, Dr Mohammad Ali Azarbaijani, Dr Mandana Gholami,
Volume 22, Issue 1 (4-2017)
Abstract

Background and Aim: Resistance training exercise is one of the most common methods in fitness programs and health programs for athletes and therapists. Manipulation of every variable of training, such as rest intervals changes the adaptation and lead to the acquisition of more strength, higher endurance or biochemical changes in the body or cells. The purpose of this study was to determine the effects of two resistance exercise (RE) protocols with different rest intervals (RI) on serum homocysteine and CRP concentrations.

Material and Methods: This study included sedentary men between 19-28years of age who were randomly divided into 3 groups: two experimental groups including RE with RI of 90 (n=10) seconds and RE with RI of 180 seconds (n=10), and a control group (n=10). Exercise protocol included 8 exercises with intensity of 50% of 1RM in the first session and 85% of 1RM in the last session. The participants' weight, body fat percentage and body mass index were measured before and after intervention.In addition fasting homocysteine and CRP levels were measured by use of ELISA method before and after the exercise program for the 3 groups. ANOVA test was used to analyze the data. We used Benferoni statistical test in order to determine and arrange the mean differences within every group.

Results: The results showed that resistance training for eight weeks with different RI can lead to significant decrease in the levels of homocysteine and CRP in healthy sedentary men.

Conclusion: Circuit resistance training with different RI decreased the serum levels of homocysteine and CRP in the healthy sedentary men. Therefore, these exercises may decrease the risk of cardiovascular diseases.

Keywords: Resistance training, Rest interval, C-reactive protein (CRP), Homocysteine

 

Received: Aug 31, 2016      Accepted: Sep 27, 2016


Dr Ali Akbar Abolfathi, Dr Zakarya Vahabzadeh, Dr Naser Mahmoodiaghdam, Davood Vahabzadeh, Dr Mohammad Saeed Hakhamanesh,
Volume 22, Issue 3 (8-2017)
Abstract

Background and Aim: Consumption of large doses of fructose have been associated with numerous metabolic abnormalities in human beings and laboratory animals. Homocysteine is believed to enhance oxidative stress while taurine has hypolipidemic effect. The present study was performed to investigate the effects of taurine and homocysteine on the oxidative stress and lipid profile in rats receiving a high fructose-containing diet.
Material and Method: In this experimental study, forty male adult Wistar rats were divided in to 5 groups. Our control group (group 1) received a normal chow.  The diets of the second to fifth groups were as following:
Group 2: A high fructose containing diet
Group 3: A high fructose containing diet + homocysteine thiolactate (50mg/kg /day)
Group 4: A high fructose containing diet + taurine (2%)
Groups 5: A high fructose containing diet + homocysteine thiolactate (50mg/kg /day)+ taurine (2%)
All the groups received the above mentioned diet for six-weeks. At the end of the experimental period, total antioxidant capacity, triglycerides, HDL, LDL, and total cholesterol of the plasma were measured. Activities of glutathione peroxidase and superoxide dismutase and level of malondialdehyde were measured in the heart and kidney tissues of the rats.
Result: Fructose alone or in addition to homocysteine significantly reduced total antioxidant capacity, glutathione peroxidase, and superoxide dismutase activities, while the levels of triglycerides and malondialdehyde increased. Taurine suppressed or attenuated these changes.
Conclusion: The results of this study confirmed the role of high fructose containing diet in inducing oxidative stress and hypertriglyceridemia. We also found that use of homocysteine deteriorated the effects of high fructose containing diet. In contrast taurine had beneficial effects and suppressed fructose induced-oxidative stress and hypertriglyceridemia.
Keywords: Fructose, Homocysteine, Taurine, Oxidative Stress, Rat.
 
Received: Dec 5, 2016      Accepted: Jan 22, 2017

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مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences
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