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Background and Aim: The aim of this study was to investigate the protective effects of Tanacetum parthenium extract (TPE) on lipid peroxidation and acute heart injury induced by carbon tetrachloride (CCl₄) in rats.
Materials and Methods: In an experimental study, 30 male Wistar rats were divided into 5 groups (n=6). Two of the groups were normal and damage control groups, other 3 groups were damage groups treated with 40, 80 and 120 mg / kg of TPE for 14 days before being damaged by CCl₄. At the end of the study we measured the activity of creatine kinase (CK-MB) isoenzyme and lactate dehydrogenase (LDH), total cholesterol (TC), HDL-C and LDL-C in serum, as well as the activity of superoxide dismutase (SOD), glutathione peroxidase (GP_X), and arylesterase (ARE) and malondialdehyde (MDA) concentration, as lipid peroxidation index, in myocardial homogenates.
Results: The results of this study showed that treatment with carbon tetrachloride significantly increased the levels of CK-MB, LDH, TC, LDL-C and MDA and decreased ARE, HDL-C, SOD and GP_X (P <0.001) in a dose dependent manner.
Conclusion: The present study demonstrated that TPE can be considered as a substance with various potential effects such as antioxidant activity and cardioprotective effects.
Key words: Tanacetum parthenium, Carbon tetrachloride, Myocardium, Lipid peroxidation, Antioxidant.
 
Received: Sep 20, 2017     Accepted: Jan 30, 2018