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Showing 5 results for Jahangir
Dr Aram Hamidi, Mahboobeh Dadfar, Dr Bijan Jahangiry, Dr Mehdi Nasr Esfahani, Fereshteh Dadfar,
Volume 11, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2006)
Abstract
Background and Aim: In spite of new medications, there is no effective treatment for OCD patients. At the present time strong association between OCD and the range of bipolar disorders is more evident. In these patients, the change of mood and the appearance of the fast mood cycles during medical therapy with antidepressants is a real hazard. In this view, medical therapy with anti OCD which is not accompanied by antidepressants, is of considerable theoretical and clinical value. This research deals with the assessment of the effect of naltrexone on OCD.
Materials and Methods: This study included 23 patients with OCD who had received clomipramine, fluextine or a combination of both for at least 3 months. Continuing these drugs with the same doses, naltrexone 25-100 mg/day was also started for the patients. Lack of response and unbearable drug side effects occurred in 3 and 4 patients respectively, leading to deletion of these patients from the study. Ultimately 16 patients (9 women and 7 men) took part in this study actively. All the patients were assessed by means of YBOCS before and after treatment. The data were analyzed by Wilcoxon, Kolomogrov-Smirnov and T tests.
Results: The grades of minor criteria for obsession, compulsion and total of YBOCS were decreased significantly after treatment and also the severity of OCD reduced. 2 patients remained free of symptoms of OCD for more than 6 months after stopping Naltrexone and the other medications. In this study, OCD was most commonly associated with bipolar disorders.
Conclusion: Regarding the small sample size and the openness of the question, the validity of these results is limited, but it appears that Naltrexone is at least effective on some subgroups of OCD especially those associated with bipolar disorders. The study of long term effects of Naltrexone after the termination of treatment is recommended in the future.
Arezo Heshmati, Omid Saed, Baytamar Jahangir Mohammadi, Saedeh Zenoozian, Fayegh Yousefi,
Volume 23, Issue 5 (Scientific Journal of Kurdistan University of Medical Sciences 2018)
Abstract
Background and Aim: Procrastination, as a pervasive phenomenon in students is interwoven with emotional problems and failure in emotion regulation. The aim of this study was to determine the efficacy of group acceptance and commitment therapy (ACT) on reduction of academic procrastination and improvement of difficulty in emotion regulation in the students of Zanjan University of Medical Sciences.
Material and Method: This was a randomized controlled clinical trial. Statistical population included all of the students of Zanjan University of Medical Sciences in the academic year 2017-2018. After screening, among 500 people, 150 students were selected on the basis of evaluation scales, in the first step. Then, we selected 40 students based on the severity of procrastination and our inclusion and exclusion criteria and divided them into two intervention groups (each group included 10 students) and a control group (n=20) using random number generator 3.1.v software. During the treatment sessions, 7 students were excluded from the two intervention groups. We used Procrastination Assessment Scale for Students (PASS) and Difficulties in Emotion Regulation Scale (DERS) for evaluation of the results. The intervention groups received eight sessions of acceptance and commitment group therapy. Data were analyzed by SPSS software.
Results: The results of repeated measure analysis of variance showed that acceptance and commitment therapy in the intervention group resulted in a significant reduction in: academic procrastination (42.1%), the total score of difficulty in emotion regulation (36.2%), difficulty in engaging in a goal- directed behavior (30.6%), impulse control difficulties (47.5%) and lack of emotional awareness (23.2%)(P<0.05). Also, the results of covariance analysis indicated that with pre-test control, acceptance and commitment therapy, explains 16.1% of the academic procrastination changes and 45.9% of the changes in emotional regulation total score in the intervention group in comparison to the changes in the control group in the long run (P <0.05).
Conclusion: The results of this study have implicit and practical implications for the specialists in order to use long-term acceptance and commitment therapy for reduction of procrastination and emotion regulation difficulties.
Mostafa Jahangir, Dr. Alireza Khorakian, Dr. Saeed Mortazavi, Dr. Ehsan Elahi,
Volume 25, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2020)
Abstract
Background and Aim: Organizational change risks are defined as the likelihood of adverse events and the negative consequences that threaten organizational change. The purpose of this research is to identify the risks of organizational change in medical universities, extracting the relationships between these risks and classifying them based on the drive power and dependence power.
Materials and Methods: In this research, which is a mix method research, organizational change risks were identified using the Glaserian grounded theory approach, and then, using the interpretative structural modeling (ISM) method, the relationships between organizational change risks are determined. Finally, using MICMAC analysis, the type of organizational change risks was identified. The study population in both quantitative and qualitative sections was faculty members and managers of medical universities. A purposive sampling method was used to select the samples.
Results: Analysis of the interviews led to the emergence of 33 organizational change risks in 10 categories. Based on interpretive structural modeling, organizational change risks were classified into five levels.
Conclusion: Given that the risks associated with knowledge management in change management, the risks related to objectives of organizational change, and the risks pertaining to employee perception of organizational change have the greatest impact on other risks, and at the same time they accept the least effect, they should be prioritized.
Gelavizh Mohammadi, Jahangir Mohammadi, Dr Sajjad Basharpour, Zahra Maghami Sharif, Dr Asma Aghebati, Dr Fayegh Yousefi,
Volume 26, Issue 6 (Scientific Journal of Kurdistan University of Medical Sciences 2021)
Abstract
Background and Aim: The current study was performed to investigate the role of activation/inhibition systems and life orientation in the students’ personality traits.
Materials and Methods: This descriptive-correlational study included 370 university students studying for Bachelor, MA and Phd degrees.The participants were selected by multistage cluster sampling. Data were collected by using scale of behavioral activation-inhibition, life orientation test-revised, and HEXACO personality inventory. Using SPSS-21 software, data were analyzed by Spearman correlation coefficient and regression analysis.
Results: among the components of behavioral activation/inhibition systems, punishment was negatively related to extraversion and conscientiousness, while there was a positive correlation between reward and extraversion, agreeableness and conscientiousness. Also a positive correlation was found between entertainment and conscientiousness. Among the components of life orientation, optimism was positively correlated with honesty-humanity, extraversion, conscientiousness, and openness to experience; pessimism was positively correlated with emotionality and negatively correlated with openness to experience and conscientiousness. The results of regression analysis revealed that among personality dimensions of HEXACO, the most frequent variances explained by behavioral activation/inhibition systems and life orientation were conscientiousness (0.17) and openness to experience (0.11), respectively. All the components of behavioral activation/inhibition systems and life orientation could explain 0.53 of HEXACO personality dimensions.
Conclusion: Predictions of all of HEXACO personality dimensions by behavioral activation/inhibition systems and life orientation components were significant. Conscientiousness and openness to experience were the most frequent variances explained by behavioral activation/inhibition systems and life orientation among personality dimensions of HEXACO.
Susan Yazdankhah, Alireza Zakeri, Saeed Khalili, Abolfazl Jahangiri, Zahraalsadat Hashemi, Alireza Heidari,
Volume 29, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2024)
Abstract
Background and Aim: Polychlorinated biphenyls (PCB) industrial pollutants are one of the most important environmental pollutants whose removal is very important. PCBs are degraded biologically by several enzymes and in a multi-step process. One of these enzymes is called DHBD (2,3-dihydroxy biphenyl 1,2-dioxygenase) and is encoded by the BphC gene. Enhancing the function of the enzyme and reducing the binding affinity of the enzyme to the inhibitor (tert-butanol) will improve the function of the enzyme and increase its efficiency. This research has been carried out in bioinformatics to strengthen the enzyme and weaken the inhibitory effect through mutation in the amino acids of the active site.
Materials and Methods: The amino acid sequence of the enzyme was obtained from the UniPprot database and to check similar sequences with PSI-BLAST method, similar sequences were searched from close to distant protein species. By performing multiple alignments of PSI-BLAST sequences, 250 sequences were matched. The results of sequencing the amino acids of the active site showed that some sites have variable amino acids and were used as candidates for mutagenesis. The position of the T-Butanol inhibitor was simulated using DISCOVERY software.
Results: By molecular docking with PYRX software between the wild enzyme and the substrate, the binding energy -6.2 Kcalmol-1and for the candidates of mutations resulting from the alignment, Phenylalanine 201 to Threonine (6. 9 Kcalmol-1) and Threonine 280 to serine (6. 8 Kcalmol-1) Calculated.
Conclusion: The more negative binding energy indicates the greater stability of this interaction in the mutant enzyme. As a result, these mutations will be able to improve the strength of the enzyme function. The simulation of the position of the inhibitor and the starting material in the enzyme showed that the distance of the inhibitor from the active site and the starting material is likely to be favorable if the interaction of the inhibitor on the amino acids of the active site is reduced and as a result, the binding stability of the biphenyl starting material with the enzyme is increased. Decreasing the inhibitory power will increase the catalytic power of the enzyme in the destruction of PCBs.
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