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Showing 8 results for Habibi
Dr Seyed Reza Mohebi, Mohammad Rostaminejad, Mohammad Amin Pourhoseingholi, Seyed Mohhammad Ebrahim Tahaei, Manizheh Habibi, Pedram Azimzadeh, Dr Faramarz Derakhshan, Dr Mohammad Reza Zali, Volume 16, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2011)
Abstract
ABSTRACT
Background and Aim: Hepatitis A is a viral infection which is transmitted via fecal-oral route and its prevalence is directly related to the public health standards. The prevalence rate of this infection is different in different populations. The aim of this study was to determine the prevalence of hepatitis A antibody and assess the need for vaccination against hepatitis A in Tehran Province.
Materials and Methods: This descriptive analytical cross-sectional study was conducted from 2006 to 2007 in Tehran Province. 448 subjects were selected by random cluster sampling. Blood samples were collected and demographic data were recorded in a questionnaire. Anti-HAV antibodies were measured by ELISA competitive method. Chi-square test and student t-test were used for statistical analysis.
Results: This study included 287 women and 161 men. Anti-HAV antibody was positive in 405 subjects (90.4%). There were no significant relationships between HAV seropositivity and different age groups or gender.
Conclusion: The results of our study showed a high prevalence of antibody in this region which is compatible with those of WHO results. Our results were similar to those obtained in Zabol City and eastern parts of Golestan Province but were not compatible with the results of the studies from Isfahan and Tabriz. At the present time there is no need for vaccination in this region.
Key words: Hepatitis A, Seroepidemiology, Tehran province, anti-Hepatitis A antibody
Conflict of Interest: Nill
Received: Feb 6, 2011 Accepted: March 18, 2011
Dr Bohlool Habibi-Asl, Dr Amir Hooshang Barati, Dr Nazila Darvishi, Dr Esmael Izadpanah, Mehdi Mafakheri, Dr Kambiz Hasanzadeh, Volume 16, Issue 4 (Scientific Journal of Kurdistan University of Medical Sciences 2012)
Abstract
ABSTRACT
Background and Aim: Long – term use of opiates induces tolerance to the analgesic effect. Despite significant investigations, the precise cellular mechanisms underlying opioid tolerance is not clear. Many studies have revealed the key role of nitric oxide in the morphin-induced tolerance. The aim of this study was to evaluate the effects of nicorandil (a nitric oxide donor and ATP sensitive potassium channel opener) and glibenclamide (an ATP sensitive potassium channel blocker) on morphine-induced tolerance.
Materials and Methods: In this study male mice weighting (20-30g) were randomly placed into groups of 8, and received different therapeutic regimens for 5 days. Different groups received either morphine (50mg/kg, i.p) + normal saline (10ml/kg, i.p), or morphine (50mg/kg, i.p) + nicorandil (2.5, 5, 10mg/kg, i.p) or morphine (50mg/kg, i.p) + glibanclamide (5, 10, 15mg/kg, i.p) every day. Nociception was assessed using a hotplate apparatus on the 6th day. The nociceptive effect was recorded when the animal licked its hind paw or jumped due to the heat effect.
Results:Our results showed that tolerance to the analgesic effect of morphine significantly increased in the group which received morphine + nicorandil (5, 10mg/kg, i.p), (p<0.05), while in morphine + glibenclamide group, tolerance significantly reduced (p<0.05).
Conclusion: The results of this study indicated that intraperitoneal injection of nicorandil increased tolerance to the analgesic effects of morphine while glibenclamide decreased tolerance. The above effect seems to be related to the role of nitric oxide (NO) and ATPsensitive potassium channel in this phenomenon.
Key word: Morphine, Nicorandil, Glibenclamide, Tolerance.
Received: Jan 9, 2011 Accepted: Nov 5, 2011
Conflict of interest: Nill
Dr Parvaneh Taymoori, Sogand Habibi, Volume 19, Issue 3 (Scientific Journal of Kurdistan University of Medical Sciences 2014)
Abstract
Background and Aim: In Iran like other developing countries, age of breast cancer is lower, in comparison to the developed countries. The purpose of this study was to investigate the relationship of mammography behavior with demographic factors and health belief model constructs to perform mammography behavior and also to assess the predictive power of this model.
Methods: In this cross-sectional study we selected 593 non lactating and non-pregnant women of 40 years of age and older without breast cancer by random clustered sampling method. Demographic data, history of previous mammography and data about HBM (perceived susceptibility, severity, self-efficacy, health motivation, benefits, and barriers) were collected by using self-report questionnaires. SPSS and LISREL software were used for data analysis.
Results: Following perceived susceptibility (r=0.48) and perceived barriers, (r=0.17), self-efficacy showed the highest correlation (r=0.61) with mammogram performance (p<0.001). Breast problem, marital status, family history of breast cancer had significant effects on mammography performance. Self-efficacy (regression coefficient=0.86) and perceived susceptibility (regression coefficient=0.65) had the most direct effect on mammography (p<0.01-0.001).
Conclusion: High power exponent of the variance in mammography behavior shows efficacy of HBM as a theoretical framework for studying the behavior of mammography. Low rate of mammogram performance indicates the need for intervention programs aimed at increasing mammography behavior.
Keyword: Breast cancer, Health belief model, Mammography, Structural equation model
Received: Feb 2, 2014 Accepted: Jun 23, 2014
Fatemeh Shaki, Emran Habibi, Masood Paran Davaji, Ramin Ataee, Volume 24, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2019)
Abstract
Background and Aim: Cupressus extract has been considered as antioxidant and free radical scavenger. In this study we evaluated the effect of hydroalcoholic extract of Cupressus sempervirens L. on blood sugar, weight and also oxidative stress parameters in experimental diabetic model of mice.
Materials and Methods: 48 male mice of albino race were made diabetic with a single dose of streptozocin (200mg./kg IP injection) for every mouse, and divided into 6 groups of 8 including: positive control(diabetic),negative control(DMSO 10% in normal saline, metformin(100mg.kg),three test groups(which received 50,100,200 mg.kg of the extract respectively by gavage for three weeks).After the treatment period, blood glucose level, weight and oxidative stress parameters such as MDA,GSH and mitochondria proliferation were measured. Using SPSS software 21, data were analyzed by ANOVA and Mann -Whitney statistical analysis.
Results: Our results showed that use of hydroalcohlolic extract of Cupressus sempervirens L. reduced blood sugar in a dose dependent way (P<0.01) but there was no significant change in the weights of the mice (P>0.05) and we found decreased oxidative stress parameters and improved hepatic mitochondrial proliferation (P<0.01).
Conclusion: According to the results of this study we can conclude that Cupressus sempervirens L. extract can be effective in reduction of blood glucose and prevention of diabetic induced damage to the liver tissue.
Mir Mohammad Jalali, Ali Faghih Habibi, Hedieh Ramezani, Volume 24, Issue 4 ( Scientific Journal of Kurdistan University of Medical Sciences 2019)
Abstract
Background and Aim: Considering the effect of middle ear infection and dental caries on the children’s quality of life and ability to grow and thrive, high prevalence rates of these diseases in children, we conducted this study to evaluate the association between dental caries status and middle ear infection in preschool children in Rasht City.
Materials and Methods: This study included 310 children between 3–6 years of age. Dental caries of the children were evaluated based on WHO decayed and filled primary teeth index. The children were divided into two groups; with and without caries and referred to Amiralmomenin Hospital in Rasht for clinical examination and audiometry test. Descriptive and analytical statistical tests were used for analysis at the significance level of 0.05.
Results: 170 girls and 140 boys with mean age of 4.58±1.02 years participated in this study. Thirty children (9.67%) had middle ear effusion. Mean value of dft index was 2.07±2.35. Probability of middle ear infection with effusion in the children with dental caries was139% more (95%CI= 1.04-5.50, OR = 2.39) than that in the children without dental caries which was statistically significant (P = 0.04). Other variables such as gender, age, education levels of fathers and mothers did not show any significant relationship with middle ear effusion (P >0.05).
Conclusion: Middle ear effusion was significantly higher in the children with dental caries than in children without dental caries. Further prospective studies are recommended for evaluation of the effects of improved oral hygine on middle ear infection.
Abolfazl Bayrami, Shadi Parvinroo, Shima Rahim Pouran, Aziz Habibi Yengjeh, Farid Mohammadi Arvanagh, Madi Bayrami, Volume 26, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2021)
Abstract
Background and Aim: The vast applications of nanotechnology in various fields including medicine, bring about the necessity to investigate the in vivo side effects of these materials. On this basis, we investigated the potential anti-diabetic activity of nanoparticles (NPs) along with toxicological effects on liver and pancreas tissue.
Materials and Methods: In this excremental research after preparation of ZnO nanoparticles and their characterization with SEM, EDX, and TEM, 30 rats were studied in 6 groups of 5 each. The groups included 1- Healthy control 2- Diabetic control 3- Diabetic - Insulin (10 U/kg) 4- Diabetic - Cranberry (150 mg/kg) 5- Diabetic-ZnO (8 mg/kg) 6- Diabetic-ZnO + extract (8 mg/kg). Diabetes was induced with alloxan monohydrate via intraperitoneal injection (170 mg/kg). Rats were treated intraperitoneal for 16 days and every four days examined for blood glucose levels, at the end of the treatment period, the liver and pancreatic tissues were analyzed by hematoxylin-eosin staining. Data were analyzed using two-way ANOVA and Tukey post hoc tests in SPSS.
Results: The analysis of nanoparticles revealed the capping of organic constituents on the surface of the biological nanoparticles. The assessment of serum samples displayed a significant decrease in blood glucose levels in the group that was treated by NPs prepared by extract when compared to that of the diabetic control group (p≤0/05). The histopathological analysis did not show any damages to the studied organs.
Conclusion: The results obtained in the present study revealed that the bio-synthesized nanoparticles not only significantly decreased the blood glucose level of diabetic rats but also had no toxic effects on the liver and pancreas tissues at the concentrations used in this study.
Dr Nasrin Hashemi-Firouzi, Dr Siamak Shahidi, Dr Simin Afshar, Dr Parisa Habibi, Dr Mahdi Ramezani, Volume 28, Issue 2 (Scientific Journal of Kurdistan University of Medical Sciences 2023)
Abstract
Background and Aim: Serotonergic system has a role in morphine dependence and withdrawal symptoms via its receptors. On the other hand, the effect of 5-HT2A receptor on withdrawal symptoms has not been evaluated completely. The aim of this study was to investigate the effect of 5-HT2A receptor stimulation on morphine withdrawal symptoms in male mice.
Materials and Methods: This experimental study included twenty eight male NMRI mice (20-25g). Morphine dependency was induced in a five- day schedule by 6, 16, 26, 36, 46, 56 and 66 mg/kg doses respectively. On the fifth day, 2 hours after a single dose of morphine, naloxone was injected (3 mg/kg) and the scores (from 0 to 3) of withdrawal symptoms including number of jumps, teeth chattering, writing, head shakes, limbs shakes, and percentage of body weight loss were recorded for 30min.The treatment group received different doses of TCB-2 (03, and 2.5mg/kg; Intraperitoneally).
Results: Withdrawal symptoms in the morphine-dependent mice were significantly more frequent than those in the control mice. Different doses of TCB-2 significantly increased some of the morphine withdrawal symptoms in the experimental groups.
Conclusion: The present study indicated that stimulation of 5-HT2A receptor via its agonist exacerbated the morphine withdrawal symptoms. Further studies are recommended to better understand the role of the 5-HT2A receptor in morphine dependence and withdrawal.
Morteza Habibi, Fatemeh Toohidinia, Volume 28, Issue 6 (Scientific Journal of Kurdistan University of Medical Sciences 2024)
Abstract
Background and Aim: To control complications in infants with respiratory distress syndrome, surfactants and auxiliary drugs such as budesonide are used to reduce the inflammatory reactions of the airways. The aim of this study is to compare the effect of intratracheal administration of survanta and survanta with budesonide in premature infants with respiratory distress syndrome.
Materials and Methods: This clinical trial included 50 premature infants with respiratory distress syndrome, hospitalized in the neonatal intensive care unit in Qazvin Children's Hospital, in 2019. The patients were divided into two groups. One group (25 cases) received intratracheal survanta (1 milliliter) + budesonide (0.25 milligram) and the other group (25 cases) received only intratracheal survanta. Using SPSS 21 software, data were analyzed by descriptive statistics, Fisher's exact and T-test (p<0.05).
Results: In the survanta+budesonide group, we found intraventricular hemorrhage in 50% and also death in 50% of the cases. In the pregnant women over 31 years of age and female infants receiving survanta + budesonide, no complications were seen. The effect of Survanta + budesonide compared to survanta on reducing complications in the infants (p = 0.048), in regard to the mothers' age group; 31 years and under 31 years (p = 0.049), and over 31 years of age (p = 0.046), female (p=0.047) and male (p=0.050) showed significant differences.
Conclusion: Administering survanta with budesonide resulted in better efficacy and fewer side effects. Budesonide can be used as an adjuvant treatment. Appropriate therapeutic measures are important for the improvement and survival of the newborns with respiratory distress syndrome.
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