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Gelayol Asadi, Sara Falahi, Misagh Rajabinejad, Parisa Feizollahi, Seyyed Hamidreza Mortazavi, Ali Gorgin Karaji, Farhad Salari, Alireza Rezaiemanesh,
Volume 28, Issue 1 (3-2023)
Abstract
Background and Aim: Allergic rhinitis is the most common chronic inflammatory disorder of the nasal mucosa. Long non-coding RNAs (lncRNA) are a group of non-coding RNAs involved in the pathogenesis of various inflammatory diseases. This study intended to evaluate the expression of long non-coding RNAs NEAT1, H19, and MALAT1 in patients with allergic rhinitis (AR) before and after treatment with budesonide and fexofenadine in comparison with fluticasone propionate and fexofenadine.
Materials and Methods:Blood samples were taken from 53 patients with allergic rhinitis (including 29 patients treated with budesonide and fexofenadine and 24 patients treated with fluticasone propionate and fexofenadine) before and one month after the initiation of treatment. The mRNA expression levels of NEAT1, H19, and MALAT1 were measured by the Real-Time PCR method.
Results: Our results showed that mRNA expression levels of H19 and MALAT1 significantly increased after treatment with budesonide and fexofenadine (p= 0.001, p = 0.002, respectively), while mRNAs expression levels of NEAT1 and H19 significantly decreased after treatment with fluticasone propionate and fexofenadine (p= 0.014, p= 0.036, respectively).
Conclusion: The combination of budesonide and fexofenadine by increasing the expression levels of MALAT1 and the combination of fluticasone propionate and fexofenadine by decreasing the expression level of NEAT1 and H19 were effective in reducing the clinical symptoms of allergic rhinitis patients.
Jamal Majidpoor, Fardin Fathi, Keywan Mortezaee,
Volume 28, Issue 4 (10-2023)
Abstract
Background and Aim: Extracellular vesicles (EVs) are key players in cellular communication and signaling in the health status and diseases. EVs have rather small size and long half-life upon secretion into circulation. This long half-life along with their immune privileged profile and the ability to carry biotherapeutics to the target cells have made EVs an issue of prominent current interest among scientists as an alternative schedule in cancer therapy.
Materials and Methods: PubMed and Google scholar were searched for relevant articles from journals with high impact factor. Among 400 articles found, 40 articles met the criteria for interpretation and were selected for descriptive review. Original and review articles published in the last ten years were used in this study.
Results: Tumor-derived EVs can be targeted for reducing cancer cell survival and increasing their apoptosis. They are also applicable for drug delivery to primary or metastatic tumors. An effective approach is to load nanoparticles into EVs for targeting a specific cell type in tumor ecosystem. Their application in nano delivery systems for cancer therapy has been the focus of attention.
Conclusion: The current studies have focused on the possibility of using EVs as biomarkers in several diseases, as targets to be removed for recovery of the patient health, and as vehicles for immunotherapy. In this review article, we discussed the importance of EV suppression or EV-based strategy for targeting solid cancers
Parand Pourghane, Parand Pourghane, Arash Pourgholaminejad,
Volume 28, Issue 6 (1-2024)
Abstract
Background and Aim: The importance of oral and dental health is more in the elderly than other age groups and various factors can affect it. The aim of this study was to investigate the relationship of oral and dental health in the elderly with the amount of salivary immunoglobulin-A (IgA), the presence of chronic and systemic diseases, and some demographic indicators such as age, gender, residential place, marital status, economic status, compliance with oral and dental hygiene, smoking and educational level. It seems that the aforementioned factors are related to the oral and dental health of the elderly.
Materials and Methods: In this systematic review we searched Google Scholar, Scopus, PubMed and SID databases for Persin and English articles between 2010 and 2020. Finally, 19 articles were selected.
Results: Based on our literature review, it seems that the presence of age-related diseases, whether chronic or systemic can influence the oral and dental health. Moreover, increased salivary IgA levels could be directly associated with oral and dental problems. Some other factors including better economic status and maintenance of oral and dental health can be related to the improvement of the oral health specially in the elderly. Although, higher education level, city of residence, lack of smoking habit, gender and marital status did not show definite effects on maintaining oral- dental health, but can affect this process.
Conclusion: Consequently, self-care educations for maintaining the oral-dental health and also follow up of the old patients with chronic systemic diseases had positive effects on the improvement of the oral and dental health.
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