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Comparison of pain intensity after laparoscopic cholecystectomy with intraperitoneal injection of bupivacaine or hydrocortisone alone in comparison with bupivacaine with morphine: a clinical trial
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Maryam Zahedi1    , Arazbardi Ghourchaei1 , Seyede Mahrokh Maddah1 , Roya Mousavi1 , Kazem Kazemnejad2 |
1- Golestan University of Medical Sciences
2- Golestan University of Medical Sciences , kazemnejad1341@yahoo.com |
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Abstract: (57 Views) |
Background & Objective: Laparoscopic cholecystectomy is used as a standard method for gallbladder resection due to less pain and bleeding than open surgery. This study was performed to evaluate and compare the severity of pain after laparoscopic cholecystectomy with the intra peritoneal injection of bupivacaine or hydrocortisone alone or bupivacaine with morphine in 5th Azar educational hospital in Gorgan in 2015.
Materials & Methods: This randomized double-blind clinical trial study was performed on 60 patients undergoing laparoscopic cholecystectomy surgery. Patients divided into 3 groups: A (30 cc of bupivacaine 0.25% intra peritoneal) B (30 cc of bupivacaine 0.25% with 2 mg morphine intraperitoneal) and C (200 mg hydrocortisone at 30 cc). The severity of pain, hemodynamic parameters is registered in specific times (at 30 minutes, 1, 4 hours after surgery. Data were analyzed by ANOVA,independent T test and chi-square in SPSS 18 software.
Results: Postoperative pain intensity was significantly higher in group C than the other two groups (P <0.05). Group A showed less pain intensity only in the first half-hour after surgery than group B but in 1 and 4 hours after surgery, pain intensity was less reported in group B.
Conclusion: it seems that the combination of bupivacaine and morphine in 1 to 4 hours after surgery has a better effect on reducing pain in patients after laparoscopic cholecystectomy.
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| Keywords: bupivacaine, hydrocortisone, morphine, pain intensity, laparoscopic cholecystectomy |
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Type of Study: Original Research |
Subject:
Medicine - General Surgery
Received: 2023/01/29 | Accepted: 2025/02/1
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