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Investigation of The Efficacy of Lymph Node Core Needle Biopsy in the Diagnosis of the cause of Lymphadenopathy
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Melika Oladzad1    , Nasser Ghaemian2 , Hemmatollah Gholinia Ahangar3 , Sahar Sadr Moharrerpour4 , Housein Ghorbani 5 |
1- Student Reseach Comitee, Babol University of Medical Sciences, Babol, Iran
2- Department of of Radiology, School of Medicine, Babol University of Medical Sciences, Babol, Iran
3- Social Determinants of Health Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
4- Assistant Professor of Pediatric Nephrology, Non-Communicable Pediatric Disease Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran
5- Cancer Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran , ghorbani7958@yahoo.com |
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Abstract: (930 Views) |
Background and Aim: Core needle biopsy (CNB) is less invasive and has fewer side effects compared to surgical procedures, and provides accurate information about the nature of the tumor. The aim of this study was to evaluate the efficacy of CNB in the diagnosis of the cause of lymphadenopathy.
Materials and Methods: In this study, 153 patients with lymphadenopathy underwent CNB from 2014 to 2018. Immunohistochemistry staining with appropriate markers was performed. Excisional biopsy, clinical and radiological data were evaluated using spss-21 softwere, data were analyzed by one way ANOVA and tukey test (p<0/05).
Results: Diffuse large B-cell lymphoma was more frequent (41%). Histopathological diagnosis of core needle biopsy was correct in 83.23% of the patients,among them 11.11% were confirmed by excisional biopsy and 88.88% by clinical and radiological findings. There was a significant relationship between the mean age of the patients and location of lymphadenopathy (P = 0.02) and also between the mean age and pathology diagnosis (P<0.001). The accuracy, sensitivity, and positive predictive value of CNB were 90%, 100%, and 90%, respectively.
Conclusion: Diagnosis of the cause of lymphadenopathy by CNB was correct in most cases and its diagnostic efficacy was confirmed. The present results recommend CNB as a suitable method without side effects for investigation of the cause of lymphadenopathy.
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| Keywords: Lymph node, Core needle biopsy, Lymphadenopathy |
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Full-Text [PDF 719 kb]
(270 Downloads)
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Type of Study: Original Research |
Subject:
Medicine - Pathology
Received: 2021/12/19 | Accepted: 2022/06/21 | Published: 2023/09/27
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Ethics code: کد اخلاق: 139802440.IR.MUBABOL.HRI.REC. Clinical trials code: ندارد
Oladzad M, Ghaemian N, Gholinia Ahangar H, Sadr Moharrerpour S, Ghorbani H. Investigation of The Efficacy of Lymph Node Core Needle Biopsy in the Diagnosis of the cause of Lymphadenopathy. SJKU 2023; 28 (4) :77-94 URL: http://sjku.muk.ac.ir/article-1-7150-en.html
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