|
|
|
 |
Search published articles |
 |
|
Showing 2 results for Cystic Fibrosis
Ms Hero Yazdanpanah, Dr Pedram Ataee, Dr Manouchehr Ahmadi Hedayati, Mr Karo Servatyari, Dr Khaled Rahmani,
Volume 27, Issue 6 (1-2023)
Abstract
Background and Aim: Cystic fibrosis is a rare genetic disease which causes widespread inflammation in the body and has a poor prognosis due to various complications, especially respiratory system involvement. The aim of this study was to estimate the incidence of cystic fibrosis and determine its epidemiological, clinical and paraclinical features in Kurdistan province, Iran, between 2010 and 2020.
Materials and Methods: This cross-sectional study included cystic fibrosis patients admitted to Besat Hospital in Sanandaj (as the only referral specialized center for pediatric diseases in Kurdistan Province) between 2010 and 2011. Epidemiological, clinical and paraclinical data of the patients were collected by a checklist. Using SPSS software version 22, data were analyzed by using Mann-Whitney test and Spearman correlation coefficient.
Results: During the study period, we found 19 patients with definite diagnosis of cystic fibrosis, 14 (73.7%) male and 5 (26.3%) female, with mean age ± standard deviation of 11.10 ± 9.7. Based on the data of the birth rate in kurdistan Province during the study period, the incidence of cystic fibrosis in Kurdistan Province was estimated to be one in 15,000 live births per year. 4 patients (21.1%), had positive family history. The main symptoms of these patients were steatorrhea (94.7%), cough (89.5%), dyspnea (78.9%), growth disorder (73.7%), heart disorders (63.2%), jaundice (57.9%) and finger clubbing (36.8%).
Conclusion: Although cystic fibrosis is not very common in this province, identifying at-risk parents and early diagnosis of the disease can be beneficial for increasing life expectancy and quality of life and reducing health costs.
Jalileh Ebn Abbas, Samaneh Rouhi, Hamed Jafarpour, Khadijeh Taherkhani, Sanaz Ahmadi, Bijan Nouri, Rasool Nasiri Kalmarzi, Farshid Gholami, Arya Jafari, Nasrin Yaghoobi,
Volume 30, Issue 1 (3-2025)
Abstract
Background and Aim: Infection caused by Pseudomonas aeruginosa (P. aeruginosa) with multiple drug resistance is one of the most important problems in patients suffering from cystic fibrosis. The purpose of this research is to investigate the prevalence of P. aeruginosa isolated with multiple drug resistance in patients suffering from cystic fibrosis.
Materials and Methods: Articles between 2008 and 2022 were searched. To perform the meta-analysis, STATA 14 software was used both in the fixed model and in the random effects model. To check the heterogeneity of the data, the Q-test (p<0.10) was used with the chi-square χ2 distribution at the 95% confidence level. Two-sided statistical tests were performed with α=0.05.
Results: The highest (100%, 95% confidence interval (CI): 0.99-1.00) and the lowest (4%, 95% CI: 0.02-0.09) prevalence was in 2021. In cross-sectional studies, the prevalence of 44% (95% CI: 0.21-0.68, odds ratio (OR) = 1.55), and in the cohort, 52% (95% CI: 0.26-0.77, OR = 1.68) was observed. Prevalence of both age groups; <20 (95% CI: 0.09-0.97, OR = 1.7, p = 0.000) and ≥ 20 (95% CI: 76. 0.30-0.76, OR = 1.7, p = 0.000) was 53%.
Conclusion: Multiple drug resistance was observed in P. aeruginosa during different years and ages. The findings of this research and the increasing antibiotic resistance of this bacterium indicate the leading challenges in the treatment of patients with cystic fibrosis, which must be properly managed and treated.
|
|
