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ABSTRACT Background and Aim: Although both insulin resistance and beta cell dysfunction contribute to pathogenesis of type II diabetes, the role of adiponectin in beta cell function has received limited attention. The objective of this study was to determine the relationship between serum adiponectin level and beta cell function. Material and methods: Forty one non athletes fat adult men between 35 and 50 years of age (BMI≥30) with type II diabetes were enrolled in this study. Serum concentrations of adiponectin, glucose, triglyceride and insulin were measured after 10-12 hours overnight fasting in all participants. Beta cell function was assessed by measuring fasting glucose and insulin level. After data collection, we used Pearson correlation test to determine the relationship between adiponectin and beta-cell function in patients with type II diabetes (p≤0.05). Result: The results of this study didn't show any significant relationship between serum adiponectin and beta cell function (p=0.145). Visceral fat (p=0.010) and serum triglycerides had a negative significant relationship with fasting adiponectin (p=0.004). Also there was a significant linear relationship between fasting adiponectin and insulin (p=0.015). Conclusion: This study demonstrated that despite the presence of a relationship between adiponectin and insulin resistance in type 2 diabetes, this hormone had no relation with beta cell function in these patients and it is not a suitable indicator for prediction of beta cell function. Keywords: Type II diabetic, adiponectin, beta cell function. Conflict of Interest: Nill Received: Dec 27, 2010 Accepted: March 18, 2011

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Background and Aim: The main purpose of this study was to compare the effect of three methods of combined training (strength and endurance) on serum adiponectin levels and insulin resistance in overweight elderly women.

Material and Methods: In this semi-experimental study, 40 elderly women (mean agepf 60.34±0.82 years, mean height: 155±0.01 cm, and mean weight: 71.72±1.89 kg) were enrolled using purposeful method and then randomly assigned to four groups: strength + endurance (n=10), endurance + strength (n=9), circulation combined (n=12), and control (n=9) groups. Serum adiponectin levels and insulin resistance index were measured before, and 48 hours after the last training session. Training programs were implemented three days a week for eight weeks. Paired t - test was used for evaluation of differences within each group and one-way ANOVA to compare the groups with one another.

Results: After eight weeks of combined training, all three experimental groups showed significant reduction in weight, body mass index (BMI), body fat percentage, and glucose (P&le0.05). Significant differences were found in weight (p=0.017) and BMI (p=0.023) between the 4 groups, but no significant differences were found in adiponectin and insulin resistance (p>0.05). 

Conclusion: According to the results of this study, despite positive changes in body composition and body fat percentage, none of the three methods of combined training caused a significant change in serum adiponectin levels and insulin resistance in the overweight elderly women.

Keywords: Combined training, Adiponectin, Insulin resistance, Aging.

Received: Apr 28, 2015      Accepted: Sep 21, 2015

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Background and Aim: A low level of adiponectin have a great effect on the breast cancer incidence and increase in adiponectin after a period of exercise training may be associated with changes in insulin resistance. Therefore, the present study aimed to investigate the effect of 12 weeks of selected Pilates exercise training on serum adiponectin level and insulin resistance in female survivors of breast cancer and its role in prevention of the recurrence.

Material and Methods: 27 breast cancer survivors (mean age 44.11±6.19 years old, BMI 29.24±4.92 kg/m²) were selected based on our inclusion criteria and randomly divided into experimental (n=14) and control (n=13) groups. The experimental group participated in a 12 weeks of selected Pilates exercise training (three session per week). During this period, the control group did not participate in any exercise training program. Data were analyzed using paired and independent t-test.

Results: Serum adiponectin level and VO₂max significantly increased, but insulin level, insulin resistance and body fat percentage significantly decreased and the FBS level had no significant change after selected Pilates exercise training (P<0.05).

Conclusion: Considering the increase in adiponectin level and decrease in insulin resistance after selected Pilates exercise training, it seems participation of the breast cancer survivors in Pilates exercise training can prevent breast cancer recurrence.

Keywords: Breast cancer, Adiponectin, Insulin resistance, Pilates

 

Received: Aug 16, 2015      Accepted: Sep 12, 2015

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Background and Aim: The purpose of this study was to investigate the effectiveness of two types of resistance exercise training along with omega-3-6-9 supplementations on some risk factors of cardiovascular diseases.
Materials and Methods: In this semi-experimental study, 60 healthy overweight young male students from Payame Noor University of Hamedan  City were randomly assigned to 6 groups of 10 subjects, including circular resistance exercise+omega3-6-9 supplementation, progressive pyramidal resistance training+omega3-6-9 supplementation, circular resistance exercise+placebo, progressive pyramidal exercise+placebo, omega3-6-9 supplement and placebo. Exercise groups completed training programs for 12 weeks. Adiponectin levels and high-sensitivity C-reactive protein (hsCRP) were measured before and after the 12-week period of physical training. Data were analyzed using paired t test, two-way ANOVA and ANCOVA.
Results: Circular resistance exercise, but not progressive pyradimal exercise, with  omega3-6-9 supplementation (P=0.000) and circular resistance exercise with placebo (P=0.007) resulted in significant increases in adiponectin levels, but not hsCRP levels. The difference between post-test mean values of the two types of exercise was significant for adiponectin, but not for hsCRP. The effect of supplementation on the level of hsCRP, independent of the type of exercise, was significant (P=0.031). There was no significant difference between the groups in relation to the hsCRP levels.
Conclusion: Circular resistance exercise, but not progressive pyramidal, increased serum adiponectin levels independent of omega3-6-9 supplementation.