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Showing 2 results for Monte Carlo Simulation
Nematollah Heidarloo, Hamid Reza Baghani, Prof. Seyed Mahmoud Reza Aghamiri, Volume 26, Issue 4 (10-2021)
Abstract
Background and Aim: Beam shaper applicator is one of the dedicated applicators for intraoperative electron radiotherapy which is usually employed for large tumors irradiation. Due to the high weight and lack of possibility of direct placement on the patient’s body, a considerable air gap exists between the applicator and patient. Therefore, determination of the effective position of electron source (SSDeff) is absolutely necessary to correct the applicator output for air gap effect and accurate delivery of the prescribed dose to the patient. The aim of this study was to determine the SSDeff for all square fields of beam shaper applicator at different electron energies using Monte Carlo (MC) simulation.
Materials and Methods: At first, the head of LIAC accelerator and beam shaper applicator were simulated by MCNPX MC code and then, the validity of the simulated model was evaluated through comparing the calculated percentage depth dose (PDD) curves at different field sizes and energies with the corresponding practiacal values. After verifying the simulated model, the SSDeff was determined for different field sizes and electron energies using inverse square law (ISL) method.
Results: The results showed that the SSDeff is a function of electron energy and radiation field size. Dependency of SSDeff on field size variations was much more than that on the alterations in the electron energy. Generally, increase in the field size or electron energy led to increase in SSDeff.
Conclusion: The determined SSDeff values for the electron beam of the beam shaper applicator in our study, can be used to correct the electron beam output for clinical purposes.
Dr. Reza Shamsabadi, Dr. Hamid Reza Baghani, Volume 30, Issue 2 (5-2025)
Abstract
Background and Aim: Cancer treatment using ionizing radiation is an effective modality for the management and control of various cancers. The presence of oxygen inside the cell causes various damages to the DNA molecule. The purpose of this study is to calculate the relative biological effectiveness (RBE) of low-energy X-rays during cancer treatment using intraoperative radiotherapy at different oxygen concentrations within the cell through a Monte Carlo (MC) simulation approach.
Materials and Methods: To estimate the RBE values in this study, the secondary electron spectrum, which was emitted from 1 cm after the bare probe surface, was calculated with the Geant4-validated MC model of the INTRABEAM system. After the calculation of the secondary electron energy spectrum, the RBE values of the emitted low-energy X-rays from the INTRABEAM system at different cell oxygen concentrations were calculated by the MCDS MC code.
Results: The results showed that the RBE values increase with the oxygen concentration increment in the cell. When the oxygen concentration increments from 0 to 100%, the RBESSB and RBEDSB values increase by about 1.6 and 2.3 times, respectively. Furthermore, in most of the studied oxygen concentrations, the RBEDSB values were greater than unity, which indicates the high relative biological effectiveness of the considered low-energy X-rays compared to high-energy photons.
Conclusion: Accordingly, it can be concluded that cell oxygen level is one of the influential factors for RBE assessments relevant to the emitted X-rays from the INTRABEAM system, where the cell sensitivity to the ionizing radiation decreases at low-oxygen levels.
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| مجله علمی دانشگاه علوم پزشکی کردستان Scientific Journal of Kurdistan University of Medical Sciences |
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