---

Background and Aim: Neonatal jaundice is a common problem in the neonates which is caused by increased unconjugated bilirubin and can result in serious neurological side effects such as kerinictrus. Several drugs have been used to treat unconjugated hyperbilirubinemia. The present study was conducted to determine the preventive effect of glycerin suppository on neonatal jaundice.
Materials and Methods: This single blind randomized clinical trial included 165 healthy term neonate without jaundice in Besat Hospital in Sanandaj. Neonates were divided into two groups. Case group treated with glycerin suppository at birth and 12 hours after birth. Control group didn’t receive glycerin suppository. Serum bilirubin levels were measured by Bili Check device (spectrophotometry) 12, 24 and 48 hours and also 5 days after birth.
Results: After 48 hours the mean serum bilirubin levels were 8.667 and 11.4412 in the case and control groups respectively, which showed no significant difference (p: 0.57) between the two groups. After 5 day the respective mean serum bilirubin levels in the case and control groups were 10.0450 and 11.05 which revealed a significant difference between the two groups (P value:0.03).
Conclusion: Use of glycerin suppository showed significant effect on reducing billirubin level in the neonates and can be considered as an adjuvant therapy for neonatal jaundice.